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Stepwise Cell Seeding on Tessellated Scaffolds to Study Sprouting Blood Vessels
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Published on: January 14, 2021

Building vascular networks.

Hojae Bae1, Amey S Puranik, Robert Gauvin

  • 1Department of Maxillofacial Biomedical Engineering and Institute of Oral Biology, School of Dentistry, Kyung Hee University, Seoul, Republic of Korea.

Science Translational Medicine
|November 16, 2012
PubMed
Summary
This summary is machine-generated.

Developing functional vascular networks in biomaterials is crucial for engineered tissues. This perspective reviews advances in biomaterial vascularization using biochemical, cellular, and microengineering approaches for regenerative medicine.

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Tissue Engineering

Background:

  • Limited clinical success of engineered tissues is partly due to the lack of vascularization.
  • Biomaterials require a vascular network for oxygen and nutrient transport essential for survival and integration post-transplantation.
  • Vascularization is a critical challenge for the clinical application of complex engineered organs.

Purpose of the Study:

  • To review recent advancements in the vascularization of biomaterials.
  • To highlight strategies for overcoming the vascularization challenge in tissue engineering.
  • To discuss the role of vascular networks in the success of engineered tissues.

Main Methods:

  • Biochemical modification of biomaterials to promote vascular growth.
  • Incorporation of exogenous cells to form vascular structures.
  • Application of microengineering technologies for creating vascular networks.

Main Results:

  • Recent advances demonstrate progress in achieving biomaterial vascularization.
  • Multiple strategies are being explored to create functional vasculature within engineered tissues.
  • Biochemical, cellular, and microengineering methods show promise for improving tissue integration.

Conclusions:

  • Functional vascularization is essential for the clinical translation of engineered tissues and organs.
  • Advances in biochemical modification, cell-based strategies, and microengineering are paving the way for improved biomaterial vascularization.
  • Overcoming the vascularization challenge is key to realizing the full potential of regenerative medicine.