Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Mechanism of Ciliary Motion

Mechanism of Ciliary Motion

The ciliary structures were first seen in 1647 by Antonie Leeuwenhoek while observing the protozoans. In lower organisms, these appendages are responsible for cell movement, while in higher organisms, these appendages help in the movement of the extracellular fluids within the body cavities.
The cilia are made up of microtubules in a 9+2 arrangement, with nine microtubule doublet ring bundles, surrounding a pair of central singlet microtubule bundles. The doublet microtubule bundles are...

Mechanism of Ciliary Motion

Mechanism of Ciliary Motion

The ciliary structures were first seen in 1647 by Antonie Leeuwenhoek while observing the protozoans. In lower organisms, these appendages are responsible for cell movement, while in higher organisms, these appendages help in the movement of the extracellular fluids within the body cavities.
The cilia are made up of microtubules in a 9+2 arrangement, with nine microtubule doublet ring bundles, surrounding a pair of central singlet microtubule bundles. The doublet microtubule bundles are...

Accessory Structures of the Eye

Accessory Structures of the Eye

Optical perception, or vision, is an extraordinary sense dependent on converting light signals received via the ocular organs. These organs, known as eyes, are securely positioned within the bony cavities of the skull, called orbits. The orbits serve a dual purpose: a protective shield for the ocular globes and a stable attachment point for the soft ocular tissues. The eye's external protective mechanisms include the eyelids, which are edged with lashes that act as a barrier against foreign...

Anatomy of the Eyeball

Anatomy of the Eyeball

The eye is a spherical, hollow structure composed of three tissue layers. The outer layer — the fibrous tunic, comprises the sclera — a white structure — and the cornea, which is transparent. The sclera encompasses some of the ocular surface, most of which is not visible. However, the 'white of the eye' is distinctively visible in humans compared to other species. The cornea, a clear covering at the front of the eye, enables light penetration. The eye's middle layer, the vascular tunic,...

Muscles of the Eye

Muscles of the Eye

The muscles of the eye are sophisticated structures that control eye movement and focus, allowing for the precise and rapid adjustments necessary for vision. The human eye is controlled by ten muscles — six extraocular muscles, three intraocular muscles, and one primary eyelid retractor muscle.
Extraocular Muscles
The six extraocular muscles surround the eyeball and control its movements. They are responsible for a wide range of eye motions, including looking up, down, left, right, and rotating...

Golgi Apparatus

Golgi Apparatus

Properly folded and assembled proteins are selectively packaged into vesicles that exit the ER. Motor proteins transport these vesicles to the Golgi apparatus for adding modifications that make these proteins functional at their destination.
The Golgi apparatus is a eukaryotic organelle that has a distinctive ribbon-like appearance. It is a primary sorting and dispatch station for cargo arriving from the ER. Newly arriving vesicles enter the cis face of the Golgi, closest to the ER, and are...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

COBT: a gene-based rare variant burden test for case-only study designs using aggregated genotypes from public reference cohorts.

Genome medicine·2026

Same author

Primary cilia as architects of the neocortex: Roles in brain development, function, and microcephaly.

Developmental cell·2025

Same author

Exome Sequencing in a Large Cohort with Ciliopathy-Related Kidney Disease.

Clinical journal of the American Society of Nephrology : CJASN·2025

Same author

Structure-Activity Analysis Reveals Perturbed Cilia-Jun N-Terminal Kinase Signaling in MAPKBP1-Associated Kidney Disease.

Kidney international reports·2025

Same author

Prostaglandin Analogs and Eupatilin as Treatments for Nephronophthisis.

Kidney international reports·2025

Same author

Fluid shear stress triggers cholesterol biosynthesis and uptake in inner medullary collecting duct cells, independently of nephrocystin-1 and nephrocystin-4.

Frontiers in molecular biosciences·2023

Search research articles

Related Experiment Video

Updated: May 16, 2026

Observation of the Ciliary Movement of Choroid Plexus Epithelial Cells Ex Vivo

Observation of the Ciliary Movement of Choroid Plexus Epithelial Cells Ex Vivo

Published on: July 13, 2015

The ciliary pocket.

Alexandre Benmerah¹

¹INSERM U1016, Institut Cochin, Paris, France. alexandre.benmerah@inserm.fr

Current Opinion in Cell Biology

|November 17, 2012

Summary

This summary is machine-generated.

Primary cilia, crucial for vertebrate development and linked to genetic disorders, have a specialized membrane domain called the ciliary pocket. This pocket at the cilium base may regulate signaling and cellular interactions.

More Related Videos

A Mouse Model of the Cornea Pocket Assay for Angiogenesis Study

A Mouse Model of the Cornea Pocket Assay for Angiogenesis Study

Published on: August 18, 2011

Impression Cytology of the Lid Wiper Area

Impression Cytology of the Lid Wiper Area

Published on: August 9, 2016

Related Experiment Videos

Last Updated: May 16, 2026

Observation of the Ciliary Movement of Choroid Plexus Epithelial Cells Ex Vivo

Observation of the Ciliary Movement of Choroid Plexus Epithelial Cells Ex Vivo

Published on: July 13, 2015

A Mouse Model of the Cornea Pocket Assay for Angiogenesis Study

A Mouse Model of the Cornea Pocket Assay for Angiogenesis Study

Published on: August 18, 2011

Impression Cytology of the Lid Wiper Area

Impression Cytology of the Lid Wiper Area

Published on: August 9, 2016

Area of Science:

Cell Biology
Developmental Biology
Genetics

Background:

Cilia are conserved organelles involved in motility and sensory functions across diverse organisms.
Primary cilia, nonmotile cilia on most vertebrate cells, are vital for developmental signaling and implicated in genetic disorders (ciliopathies).
A specific membrane domain, the ciliary pocket, at the base of primary cilia has been historically overlooked.

Purpose of the Study:

To investigate the structure and potential functions of the ciliary pocket.
To understand the role of the ciliary pocket in cellular processes.
To highlight the significance of this membrane domain in cilia biology.

Main Methods:

Literature review and synthesis of existing research on cilia and the ciliary pocket.
Analysis of historical and recent descriptions of ciliary structures.
Comparative analysis of ciliary pockets in different cell types.

Main Results:

The ciliary pocket is present at the base of primary cilia and some motile cilia.
This domain is proposed to serve as a platform for vesicular trafficking.
It may also function as an interface with the actin cytoskeleton.

Conclusions:

The ciliary pocket is a significant, understudied structure with potential roles in cilia-associated transport and cytoskeletal interactions.
Further research is needed to fully elucidate the functions of the ciliary pocket.
Understanding the ciliary pocket may offer new insights into ciliopathies and developmental processes.