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Related Concept Videos

Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Essential Minerals for Bone Health01:31

Essential Minerals for Bone Health

The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...

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Related Experiment Video

Updated: May 16, 2026

Cortical Bone Assessment Using Ultrasonic Guided Waves: A Reproducibility Study in a Healthy Population
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Cortical Bone Assessment Using Ultrasonic Guided Waves: A Reproducibility Study in a Healthy Population

Published on: January 31, 2025

Better tools for assessing osteoporosis.

B Lawrence Riggs1, Sundeep Khosla, L Joseph Melton

  • 1Endocrine Research Unit, College of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA

The Journal of Clinical Investigation
|November 17, 2012
PubMed
Summary
This summary is machine-generated.

Dual photon absorptiometry (DPA) revealed significant vertebral bone loss in osteoporotic women with fractures 30 years ago. This finding advanced axial skeleton research and led to modern osteoporosis assessment tools.

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Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model
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Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model

Published on: September 28, 2017

Related Experiment Videos

Last Updated: May 16, 2026

Cortical Bone Assessment Using Ultrasonic Guided Waves: A Reproducibility Study in a Healthy Population
09:02

Cortical Bone Assessment Using Ultrasonic Guided Waves: A Reproducibility Study in a Healthy Population

Published on: January 31, 2025

Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model
07:12

Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model

Published on: September 28, 2017

Area of Science:

  • * Bone densitometry
  • * Osteoporosis research
  • * Axial skeleton biomechanics

Background:

  • * Osteoporosis diagnosis and treatment efficacy assessment rely on accurate bone density measurements.
  • * Early research into vertebral fractures in women laid the groundwork for current diagnostic standards.
  • * Dual photon absorptiometry (DPA) was a pioneering technique in bone mineral density assessment.

Observation:

  • * Thirty years ago, DPA was used to compare bone density in osteoporotic women with vertebral fractures versus controls.
  • * A significant difference in vertebral bone loss was observed between the two groups.

Findings:

  • * Osteoporotic women with vertebral fractures exhibited substantially greater bone loss in the vertebrae compared to controls.
  • * This initial DPA finding highlighted the critical role of axial bone loss in fracture development.

Implications:

  • * The study pioneered research into the factors influencing bone loss and fractures in the axial skeleton.
  • * It paved the way for the development of advanced imaging techniques like dual-energy x-ray absorptiometry (DXA) and quantitative computed tomography (QCT).
  • * These subsequent technologies are now the gold standard for evaluating osteoporosis severity and monitoring treatment effectiveness.