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Related Concept Videos

Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists01:18

Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists

Endothelins (ETs) are potent vasoactive peptides critical in the human body's various physiological and pathological processes. One of the most promising therapeutic strategies for treating pulmonary arterial hypertension (PAH) involves counteracting the effects of these endothelins using a class of drugs known as endothelin receptor antagonists.
ETs are synthesized through a complex sequence of enzymatic steps, primarily involving an enzyme referred to as endothelin-converting enzyme (ECE). Of...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists

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Venous Thrombosis III: Interprofessional Care

Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
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Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
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Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors

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Related Experiment Video

Updated: May 16, 2026

Tumor Treating Field Therapy in Combination with Bevacizumab for the Treatment of Recurrent Glioblastoma
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Tumor Treating Field Therapy in Combination with Bevacizumab for the Treatment of Recurrent Glioblastoma

Published on: October 27, 2014

Brentuximab vedotin.

Changchun Deng1, Beiqing Pan, Owen A O'Connor

  • 1Center for Lymphoid Malignancies, Columbia University Medical Center, New York, NY 10022, USA. cd2448@mail.cumc.columbia.edu

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
|November 17, 2012
PubMed
Summary
This summary is machine-generated.

Brentuximab vedotin, a CD30-specific antibody-drug conjugate, shows high response rates in Hodgkin lymphoma and anaplastic large cell lymphoma. This targeted therapy is changing treatment for CD30-positive lymphomas.

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04:48

Chemotherapy-induced Vascular Toxicity - Real-time In vivo Imaging of Vessel Impairment

Published on: January 7, 2015

Area of Science:

  • Oncology
  • Pharmacology
  • Immunology

Background:

  • Brentuximab vedotin (SGN-35) is an FDA-approved CD30-specific antibody-drug conjugate.
  • It is indicated for relapsed Hodgkin lymphoma post-ASCT or alternative chemotherapy, and for systemic anaplastic large cell lymphoma (ALCL) post-chemotherapy.

Purpose of the Study:

  • To review the mechanism of action, preclinical, and clinical activity of brentuximab vedotin.
  • To discuss its impact on managing CD30-positive lymphoproliferative malignancies.

Main Methods:

  • Review of preclinical data and clinical trial results.
  • Analysis of response rates and complete response rates in Hodgkin lymphoma and ALCL patients.

Main Results:

  • Brentuximab vedotin demonstrated high overall response rates (>70% for Hodgkin lymphoma, >80% for ALCL).
  • Complete response rates were 34% for Hodgkin lymphoma and 57% for ALCL.
  • The agent shows significant efficacy as a single agent in relapsed/refractory settings.

Conclusions:

  • Brentuximab vedotin offers a highly effective treatment option for specific CD30-positive lymphomas.
  • Its success suggests a paradigm shift in managing these malignancies, with potential for frontline use.