Related Experiment Video
Updated: Jan 11, 2026
08:31
Bioprinting of Hydrogel Tumor Slices as a 3D Model for Mantle Cell Lymphoma
Published on: September 12, 2025
744
Emerging first-line treatment approaches for mantle cell lymphoma
Changchun Deng1, Nikki Agarwal2, Ariel D Sindel1
1UH Seidman Cancer Center, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Leukemia & Lymphoma
|November 17, 2025
Summary
Front-line treatment for mantle cell lymphoma (MCL) is advancing with Bruton's tyrosine kinase inhibitors (BTKi). These novel therapies show high efficacy, potentially reducing the need for autologous stem cell transplant (ASCT) in MCL management.
Area of Science:
- Oncology
- Hematology
- Clinical Trials
Background:
- Mantle cell lymphoma (MCL) treatment is rapidly evolving.
- Novel therapeutic agents are changing the front-line management landscape.
Purpose of the Study:
- To review key clinical trials informing current MCL treatment strategies.
- To guide oncologists in managing untreated MCL with recent advancements.
Main Methods:
- Analysis of recent clinical trial data on front-line MCL treatment.
- Review of historical regimens for comparative context.
Main Results:
- Bruton's tyrosine kinase inhibitors (BTKi) show high efficacy in front-line MCL, with or without chemotherapy.
- Combination of BTKi with venetoclax is effective for high-risk MCL with TP53 alterations.
- Autologous stem cell transplant (ASCT) may not offer additional benefit after effective front-line BTKi therapy and can be toxic.
Conclusions:
- BTKi should be considered for the front-line treatment of MCL.
- Emerging data support a shift towards non-chemotherapy-based BTKi regimens.
- The role of ASCT in MCL requires re-evaluation in the context of novel therapies.
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