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NCCN Guidelines® Insights: Management of Immunotherapy-Related Toxicities, Version 2.2024
John A Thompson1, Bryan J Schneider2, Julie Brahmer3
11Fred Hutchinson Cancer Center.
Journal of the National Comprehensive Cancer Network : JNCCN
|November 13, 2024
Summary
The NCCN Guidelines offer crucial management strategies for potentially fatal toxicities arising from cancer immunotherapies like immune checkpoint inhibitors and CAR T-cell therapies. These updates focus on addressing newly identified adverse events to improve patient care.
Area of Science:
- Oncology
- Immunotherapy
- Clinical Guidelines
Background:
- Cancer immunotherapy, including immune checkpoint inhibitors and CAR T-cell therapies, can cause severe, life-threatening toxicities.
- Effective management of these immune-related adverse events (irAEs) is critical for patient safety and treatment success.
Purpose of the Study:
- To provide oncology practitioners with updated guidance on managing toxicities associated with various cancer immunotherapies.
- To highlight recent revisions in the NCCN Guidelines for the Management of Immunotherapy-Related Toxicities.
Main Methods:
- Review and synthesis of the latest NCCN Guidelines for Immunotherapy-Related Toxicities.
- Inclusion of management strategies for toxicities related to immune checkpoint inhibitors, CAR T-cell therapies, and lymphocyte engagers.
Main Results:
- The guidelines cover a broad spectrum of irAEs, offering practical approaches for their management.
- Recent updates address emerging toxicities and refine existing recommendations for established ones.
Conclusions:
- Adherence to updated NCCN Guidelines is essential for optimizing the care of patients undergoing cancer immunotherapy.
- Proactive and informed management of irAEs can mitigate risks and improve patient outcomes.
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