Related Experiment Video
Updated: May 16, 2026

A Novel Bayesian Change-point Algorithm for Genome-wide Analysis of Diverse ChIPseq Data Types
Published on: December 10, 2012
Genome-wide identification and evolutionary analysis of B7-H3
1Center for System Biology, Soochow University, Suzhou 215006, China. Melissa.duan@hotmail.com
Abstract:
B7-H3 is an immune co-stimulatory molecule of the B7 family that contains a set of immunoglobulin-V (IgV) and immunoglobulin-C (IgC) domains. To explore the evolutionary process of B7-H3 gene, we conducted a genome-wide structure and phylogenetic analysis of B7-H3 genes in currently sequenced genomes. On the basis of the available data, 17 mammalian B7-H3 genes were predicted to have tandemly duplicated 4Ig domains. The analysis of gene structure and phylogenesis reveal that these 4IgB7-H3 genes resulted from domain duplication. Nevertheless, no difference in function has been observed between the two isoforms. It is more likely that domain duplication in 4IgB7-H3 leads to functional redundancy.
More Related Videos
13:19Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer
Published on: November 2, 2013
10:09Isolation and Cultivation of Neural Progenitors Followed by Chromatin-Immunoprecipitation of Histone 3 Lysine 79 Dimethylation Mark
Published on: January 26, 2018
Related Concept Videos
Evolutionary Relationships through Genome Comparisons
Modern Molecular Taxonomy
Genomic DNA in Eukaryotes