Iron homeostasis and its disorders in mice and men: potential lessons for rhinos

During the last decade, there have been remarkable advances in the understanding of iron homeostasis and its disorders. This review summarizes our presentation at the International Workshop on Iron Storage Disease in Black Rhinos that was held in Orlando, Florida, USA, from 23 to 26 February 2011, and it is directed to veterinarians and nutritional experts who treat rhinoceroses. This review summarizes the current knowledge in humans and mice regarding the physiology and molecular basis of iron overload, and it explores how it can be applied to the problem of iron overload in captive rhino populations.