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[Expression of fascin and correlation with MVD in sinonasal inverted papilloma]
1Department of Otolaryngology-Head and Neck Surgery, the First Affiliated Hospital of Nanchang University, Nanchang, 330006, China.
Objective:
To investigate the expression of Fascin in sinonasal inverted papilloma (SNIP) and the relationship between Fascin expression and microvessel density (MVD).
Method:
The expression of Fascin and CD34 were determined by immunohistochemistry in 30 cases of SNIP, 12 cases of nasal squamous cell carcinoma (NSCC) and 10 cases of normal inferior turbinate (IT) tissues. Meanwhile, CD34, measure of MVD, was counted at the same time.
Result:
Fascin was expressed in 17 of 30 (56.6%) cases of SNIP, 10 of 12 (83.3%) cases of NSCC and 2 of 10 (20.0%) cases of normal IT tissues. Expression of Fascin was significantly increased in SNIP and NSCC compared to normal tissues (P < 0.01). MVD counts was 23.64 +/- 2.74, 45.10 +/- 5.45, 74.76 +/- 7.32, respectively (P < 0.01). There was a positive correlation between the expression of Fascin and MVD counts.
Conclusion:
The high expression of Fascin and angiogenesis are significantly associated with biological behaviour of SNIP. Fascin may play an important role in the pathogenesis of SNIP and NSCC and synergic role with angiogenesis in progression of SNIP.
Insights
Fascin expression and angiogenesis are elevated in sinonasal inverted papilloma (SNIP) and nasal squamous cell carcinoma (NSCC). High Fascin levels correlate with increased microvessel density (MVD), suggesting a role in tumor progression.
Area of Science:
- Oncology
- Pathology
- Molecular Biology
Context:
- Sinonasal inverted papilloma (SNIP) is a benign tumor with malignant potential.
- Understanding the molecular mechanisms driving SNIP progression is crucial for effective treatment.
Purpose:
- To investigate Fascin protein expression in SNIP tissues.
- To determine the relationship between Fascin expression and microvessel density (MVD) in SNIP.
Summary:
- Fascin expression was significantly higher in SNIP and nasal squamous cell carcinoma (NSCC) compared to normal tissues.
- A positive correlation was observed between Fascin expression and MVD, a marker of angiogenesis.
- These findings suggest Fascin and angiogenesis play a synergistic role in SNIP pathogenesis and progression.
Impact:
- Highlights the potential role of Fascin as a biomarker for SNIP.
- Provides insights into the molecular pathways involved in SNIP tumorigenesis.
- May inform the development of targeted therapies for SNIP and related malignancies.
