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Related Concept Videos

Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:46

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Drug Discovery: Overview01:26

Drug Discovery: Overview

Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
Pharmacogenetics and Pharmacogenomics: Overview01:29

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Pharmacogenetics and pharmacogenomics examine how genetic factors influence an individual's response to drugs. While pharmacogenetics focuses on the impact of specific genetic variants on drug effects, pharmacogenomics takes a broader approach, studying how genetic variation across populations contributes to differences in drug responses. These fields aim to explain why individuals may experience varying levels of efficacy or adverse reactions to the same medication.Variability in drug...

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Methylated DNA Immunoprecipitation
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Current trends in epigenetic drug discovery.

Diana A Stolfa1, Oliver Einsle, Wolfgang Sippl

  • 1Institute of Pharmaceutical Sciences, University of Freiburg, Albertstrasse 25, 79104 Freiburg, Germany.

Future Medicinal Chemistry
|November 20, 2012
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Summary

Epigenetic drug discovery offers promising new therapies. This review covers case studies in epigenetic modification sequencing, assay development, screening, medicinal chemistry, and clinical applications.

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Area of Science:

  • Biomedical research
  • Pharmacology
  • Genetics

Background:

  • Epigenetics is a rapidly advancing field with significant implications for human health.
  • Epigenetic drug discovery represents a promising frontier for developing novel therapeutics.
  • The first epigenetic inhibitors have already gained regulatory approval for clinical use.

Purpose of the Study:

  • To provide a comprehensive review of epigenetic drug discovery.
  • To highlight diverse case studies across the drug development pipeline.
  • To illustrate the journey from basic epigenetic research to clinical application.

Main Methods:

  • Review of existing literature and case studies.
  • Analysis of methodologies in epigenetic modification sequencing.
  • Examination of assay development, high-throughput screening, and medicinal chemistry approaches.
  • Inclusion of in vivo testing and clinical trial data.

Main Results:

  • Demonstration of successful epigenetic drug discovery through various case studies.
  • Illustration of challenges and successes in developing epigenetic therapies.
  • Evidence of the translation of epigenetic research into clinical treatments.

Conclusions:

  • Epigenetic drug discovery is a viable and expanding area with approved treatments.
  • The presented case studies showcase the multifaceted nature of developing epigenetic drugs.
  • Further research and development in epigenetics hold potential for future therapeutic breakthroughs.