Two new compounds from Hicriopteris glauca and their potential antitumor activities

Chemical examination of the EtOAc extract from the stems of Hicriopteris glauca (Thunb) Ching. led to the isolation of two new compounds: lunularic acid 4'-glucoside and 2,9-dihydroxy-4,7-megastigmadiene-3-O-β-glucoside. Their structures were elucidated on the basis of spectral analysis and by comparing their spectral data with those in literature. Two compounds, along with the petroleum ether, chloroform, EtOAc, and n-BuOH extracts, were tested for cytotoxic activities. Only the n-BuOH extract showed antitumor activity against human melanoma A375 cells with IC₅₀ values of 0.80 μg/ml.