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Genomic biomarkers for patient selection and stratification: the cancer paradigm

Sterghios Athanasios Moschos1

  • 1Molecular & Applied Biosciences, School of Life Sciences, University of Westminster, London, W1W 6UW, UK. s.moschos@westminster.ac.uk

Bioanalysis
|November 20, 2012
PubMed

Insights

Personalized medicine, driven by the human genome project, unifies drug and biomarker discovery. Biomarker strategies are crucial for effective cancer treatment and preventing late-stage drug failures.

Area of Science:

  • Biomedical Science
  • Genomics
  • Translational Medicine

Background:

  • The human genome project catalyzed advancements in disease diagnosis and treatment.
  • Oncology has pioneered personalized medicine through targeted therapies and biomarker identification.

Purpose of the Study:

  • To review challenges in translating biomarker assay information into clinical decisions.
  • To assess the impact of personalized genome sequencing on companion diagnostics.

Main Methods:

  • Historical review of biomarker strategies.
  • Analysis of case studies in oncology.
  • Assessment of personalized genome sequencing's role.

Main Results:

  • Biomarker strategies have improved patient selection for targeted therapies.
  • Biomarkers have rescued drugs from late-stage failure.
  • Personalized medicine is transforming drug development pipelines.

Conclusions:

  • Overcoming challenges in biomarker translation is key for clinical actionability.
  • Personalized genome sequencing will significantly impact companion diagnostic development and commercialization.

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