Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Tissue Transplantation

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Research progress of artificial intelligence in high-throughput drug screening.

Frontiers in pharmacology·2026

Same author

Prior copper intrauterine device use and reproductive outcomes after embryo transfer in IVF/ICSI cycles: a propensity score-matched cohort study.

Frontiers in cell and developmental biology·2026

Same author

Effect of pericentric inversion of chromosome 9 on reproductive outcomes in assisted reproductive technology: a propensity score-matched cohort study.

Frontiers in endocrinology·2026

Same author

Triglyceride-glucose index and assisted reproductive outcomes in non-PCOS women: evidence from a propensity score-weighted cohort of 9,903 patients.

Journal of ovarian research·2026

Same author

[Establishment of a canine model of vascularized allogeneic spinal cord transplantation and preliminary study on spinal cord continuity reconstruction].

Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery·2025

Same author

cTAGE5 is essential for adipogenesis and adipose tissue development.

Nature communications·2025

Search research articles

Related Experiment Video

Updated: May 16, 2026

Vascularized Composite Hand Allograft Procurement and Preparation for Distal and Proximal Forearm Allotransplantation: A Stepwise Approach

Vascularized Composite Hand Allograft Procurement and Preparation for Distal and Proximal Forearm Allotransplantation: A Stepwise Approach

Published on: May 23, 2025

The next frontier in composite tissue allotransplantation.

Xiaoping Ren¹, Michael C Laugel

¹Clinical Translational Medicine Center, Harbin Medical University, China. renxg@uc.edu

CNS Neuroscience & Therapeutics

|November 20, 2012

Summary

Composite tissue allotransplantation (CTA) has advanced significantly since the 1950s, with hand allografts pioneering the field. Ethical considerations, particularly for allo-head and body reconstruction (AHBR), remain a key challenge for future progress.

More Related Videos

Vascularized Composite Upper Limb Allograft Harvesting for Proximal Arm Allotransplantation

Vascularized Composite Upper Limb Allograft Harvesting for Proximal Arm Allotransplantation

Published on: June 13, 2025

Surgical Approach to Full Soft Tissue Face Allograft Procurement for Vascularized Composite Allotransplantation

Surgical Approach to Full Soft Tissue Face Allograft Procurement for Vascularized Composite Allotransplantation

Published on: December 30, 2025

Related Experiment Videos

Last Updated: May 16, 2026

Vascularized Composite Hand Allograft Procurement and Preparation for Distal and Proximal Forearm Allotransplantation: A Stepwise Approach

Vascularized Composite Hand Allograft Procurement and Preparation for Distal and Proximal Forearm Allotransplantation: A Stepwise Approach

Published on: May 23, 2025

Vascularized Composite Upper Limb Allograft Harvesting for Proximal Arm Allotransplantation

Vascularized Composite Upper Limb Allograft Harvesting for Proximal Arm Allotransplantation

Published on: June 13, 2025

Surgical Approach to Full Soft Tissue Face Allograft Procurement for Vascularized Composite Allotransplantation

Surgical Approach to Full Soft Tissue Face Allograft Procurement for Vascularized Composite Allotransplantation

Published on: December 30, 2025

Area of Science:

Transplantation immunology
Regenerative medicine
Surgical innovation

Background:

Composite tissue allotransplantation (CTA) has evolved from theoretical concepts to clinical practice since the late 20th century.
Hand allografts represent the pioneering application of CTA, overcoming initial skepticism regarding practicality and methodology.
Continuous advancements in immunosuppression protocols and surgical techniques have refined CTA procedures.

Observation:

Ethical debates, rather than surgical limitations, appear to be the primary impediment to CTA's broader application.
Allo-head and body reconstruction (AHBR) presents unique ethical challenges that require careful consideration.
Recent successes in CTA warrant an exploration of its potential for more complex reconstructive procedures.

Findings:

The history of CTA demonstrates a progression from theoretical research to established clinical reality.
Understanding the ethical landscape is crucial for developing viable models for advanced CTA, including AHBR.
The feasibility of AHBR as a clinical option necessitates addressing ethical concerns alongside surgical design.

Implications:

Addressing ethical concerns is paramount for the continued evolution and expansion of composite tissue allotransplantation.
Developing a framework for ethical considerations in AHBR could pave the way for this complex reconstructive frontier.
Further research into the ethical and surgical aspects of AHBR is needed to determine its clinical viability.