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Lineage Commitment

Lineage Commitment

Commitment is the process whereby stem cells:

T Cell Activation and Clonal Selection

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...

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Related Experiment Video

Updated: May 16, 2026

Study of Dendritic Cell Development by Short Hairpin RNA-Mediated Gene Knockdown in a Hematopoietic Stem and Progenitor Cell Line In vitro

Study of Dendritic Cell Development by Short Hairpin RNA-Mediated Gene Knockdown in a Hematopoietic Stem and Progenitor Cell Line In vitro

Published on: March 7, 2022

Re(de)fining the dendritic cell lineage.

Ansuman T Satpathy¹, Xiaodi Wu, Jörn C Albring

¹Department of Pathology and Immunology, Washington University in St. Louis, School of Medicine, St. Louis, Missouri, USA.

Nature Immunology

|November 20, 2012

Summary

This summary is machine-generated.

Dendritic cells (DCs), crucial immune cells, are better understood thanks to new research. Advances in progenitor characterization, differentiation factors, and genetic tools clarify DC lineage and function in health and disease.

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Last Updated: May 16, 2026

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Area of Science:

Immunology
Cell Biology

Background:

Dendritic cells (DCs) are key regulators of innate and adaptive immunity.
Their study is challenging due to similarities with monocytes and macrophages.
Understanding DC lineage and function is critical for immunology.

Purpose of the Study:

To summarize recent advances in dendritic cell (DC) biology.
To clarify the nature of the DC lineage.
To provide insights into DC function in health and disease.

Main Methods:

Characterization of lineage-restricted progenitors in bone marrow.
Identification of cytokines and transcription factors for DC differentiation.
Development of genetic tools for in vivo DC visualization and depletion.

Main Results:

Clarification of the dendritic cell lineage.
Enhanced understanding of DC differentiation pathways.
New insights into DC roles in physiological and pathological processes.

Conclusions:

Significant progress has been made in understanding dendritic cell biology.
Genetic tools and differentiation studies have advanced the field.
These findings deepen our knowledge of immune responses mediated by DCs.