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Updated: May 16, 2026

Developing a Rat Model for Bipolar Disorder
Published on: May 2, 2025
Prodromes, precipitants, and risk factors for relapse in bipolar disorder
Klara Latalova1, Jan Prasko, Tomas Diveky
1Department of Psychiatry, University Hospital Olomouc, Czech Republic. klaralat@centrum.cz
Objective:
The purpose of this qualitative review is to examine prodromes, precipitants, and risk factors for repeated episodes of mania and depression in bipolar disorder.
Methods:
PubMed, EMBASE, and PsychInfo were searched for "bipolar disorder" in conjunction with: "prodromes", "triggers", and "life change events".
Results:
Phenomenology and prevalence of prodromes, precipitants, and risk factors are described, and their therapeutic implications are outlined.
Conclusions:
Most patients with bipolar disorder are able to recognize their prodromes. This ability depends largely on insight. Psychoeducation focused on improving various aspects of insight, including treatment adherence, reduces incidence of relapses in bipolar disorder.
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