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Updated: May 26, 2026

Closed-Loop Neurostimulation for Biomarker-Driven, Personalized Treatment of Major Depressive Disorder
Published on: July 7, 2023
Psychedelics and neurostimulation for treatment resistant psychiatric disorders
Filip Blazek1, Klara Latalova2, David Krahulik3
1Department of Neurosurgery, University Hospital Olomouc, Olomouc Zdravotniku 248/7, 779 00, Olomouc, Czech Republic. filip.blazek@fnol.cz.
Abstract:
Psychedelic-assisted therapy and neurostimulation represent converging approaches to modulating dysfunctional brain circuits in treatment-resistant psychiatric disorders. This Perspective outlines shared mechanisms involving neuroplasticity and network reconfiguration, and examines ethical, regulatory, and infrastructural barriers to their translation. Bridging neuroscience, psychiatry, and policy, it proposes strategies for integrating these innovative interventions into evidence-based, circuit-focused models of mental health care.
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