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Published on: January 19, 2019
Miscellaneous agents--cytotoxics and hormonal agents.
1Department of Internal Medicine, Division of Hemtology-Oncology, Harold C Simmons Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA. david.gerber@utsouthwestern.edu
Summary
This review highlights novel cytotoxic and hormonal agents presented, including microtubule inhibitors, a topoisomerase inhibitor, and an alkylating agent for cancer therapy. It also covers new hormonal agents like aromatase inhibitors and receptor antagonists.
Area of Science:
- Oncology
- Pharmacology
Background:
- Cancer treatment research continuously seeks novel therapeutic agents.
- Advancements in drug development target various cellular mechanisms and signaling pathways.
Purpose of the Study:
- To summarize key novel cytotoxic and hormonal agents presented at a recent scientific meeting.
- To provide an overview of emerging drug classes and specific agents in oncology.
Main Methods:
- Review of 19 presentations on miscellaneous new agents.
- Categorization of agents into cytotoxic and hormonal therapies.
- Identification of specific drug examples within each category.
Main Results:
- Novel cytotoxic agents discussed include microtubule inhibitors (eribulin, nanoparticle albumin-bound paclitaxel, peptide-bound paclitaxel), a topoisomerase inhibitor (nanoirinotecan), and an alkylating agent (palifosfamide).
- Novel hormonal agents include an aromatase inhibitor (anastrazole), an estrogen receptor antagonist (fulvestrant), and a selective androgen receptor modulator (GTx-024).
Conclusions:
- Several promising new cytotoxic and hormonal agents are emerging in cancer research.
- These novel agents represent diverse mechanisms of action for potential therapeutic application.
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