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Related Concept Videos

Role of Matrix Metalloproteases in Degradation of ECM01:23

Role of Matrix Metalloproteases in Degradation of ECM

Matrix metalloproteases (MMPs) are enzymes involved in the hydrolysis of proteins and glycoproteins of the extracellular matrix. MMPs are essential for the migration and proliferation of cells through the dense matrix network, throughout embryonic development, and throughout morphogenesis. The first MMP activity discovered was a collagenase in a tadpole's tail undergoing metamorphosis. The active collagen deposition and modifications lead to the morphogenesis of tadpoles into the adult body.
A...

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Related Experiment Video

Updated: May 16, 2026

Phosphorus-31 Magnetic Resonance Spectroscopy: A Tool for Measuring In Vivo Mitochondrial Oxidative Phosphorylation Capacity in Human Skeletal Muscle
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Phosphorus-31 Magnetic Resonance Spectroscopy: A Tool for Measuring In Vivo Mitochondrial Oxidative Phosphorylation Capacity in Human Skeletal Muscle

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Circulating MMP-9 during exercise in humans.

E Rullman1, K Olsson, D Wågsäter

  • 1Department of Laboratory Medicine, Division of Clinical Physiology C1-88 Karolinska Institutet, Karolinska University Hospital, Huddinge 141 86, Stockholm, Sweden. eric.rullman@ki.se

European Journal of Applied Physiology
|November 20, 2012
PubMed
Summary
This summary is machine-generated.

A single exercise bout increases circulating matrix metalloproteinase 9 (MMP-9) and causes collagen IV release from muscles, indicating extracellular matrix remodeling. However, MMP-9 does not appear to originate from exercising skeletal muscle.

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Human Skeletal Muscle Biopsy Procedures Using the Modified Bergström Technique
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Last Updated: May 16, 2026

Phosphorus-31 Magnetic Resonance Spectroscopy: A Tool for Measuring In Vivo Mitochondrial Oxidative Phosphorylation Capacity in Human Skeletal Muscle
09:40

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Published on: January 19, 2017

Human Skeletal Muscle Biopsy Procedures Using the Modified Bergström Technique
07:20

Human Skeletal Muscle Biopsy Procedures Using the Modified Bergström Technique

Published on: September 10, 2014

Area of Science:

  • Exercise Physiology
  • Biochemistry
  • Cellular Biology

Background:

  • Matrix metalloproteinase 9 (MMP-9) degrades extracellular matrix (ECM) proteins.
  • Exercise elevates circulating MMP-9, but its source and link to ECM remodeling are unclear.

Purpose of the Study:

  • Investigate exercise-induced ECM remodeling and basal lamina degradation.
  • Determine if circulating MMP-9 originates from exercising skeletal muscle.

Main Methods:

  • Ten healthy males performed a single cycle exercise bout.
  • Arteriovenous blood samples measured collagen IV and MMP-9.
  • Assessed neutrophil degranulation markers (elastase, NGAL).

Main Results:

  • Plasma collagen IV increased, with an arteriovenous difference noted at 27 minutes.
  • Plasma MMP-9 levels rose at 27 and 57 minutes, but without an arteriovenous difference.
  • No changes in elastase or NGAL indicated neutrophil involvement.

Conclusions:

  • Exercise induces basal lamina turnover in skeletal muscle, evidenced by collagen IV release.
  • Elevated circulating MMP-9 post-exercise likely originates from non-skeletal muscle sources.