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Related Concept Videos

Sutures of the Skull01:22

Sutures of the Skull

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The human skull is composed of several bones that come together to protect the brain and support the structures of the face. The junctions where these bones meet are called sutures.
Sutures are immobile joints between adjacent bones of the skull. The narrow gap between the bones is filled with dense, fibrous connective tissue that unites the bones. The long sutures located between the skull bones are not straight but instead follow irregular, tightly twisting paths. These twisting lines tightly...
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Cranial Bones: Superior and Posterior View01:14

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The superior view of the cranium shows the frontal and paired parietal bones.
The frontal bone is the single bone that forms the forehead. At its anterior midline, between the eyebrows, there is a slight depression called the glabella. The frontal bone also forms the supraorbital margin of the orbit. Near the middle of this margin is the supraorbital foramen, the opening that provides passage for a sensory nerve to the forehead. The frontal bone is thickened just above each supraorbital margin,...
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Overview of the Skull01:08

Overview of the Skull

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The cranium (skull) is the skeletal structure of the head that supports the face and protects the brain. It is subdivided into the facial bones and the brain case, or cranial vault. The facial bones underlie the facial structures, form the nasal cavity, enclose the eyeballs, and support the teeth of the upper and lower jaws.
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Cranial Bones: Lateral View01:27

Cranial Bones: Lateral View

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The lateral view of the cranium is dominated by temporal, sphenoid, and ethmoid bones.
The temporal bone forms the lower lateral side of the skull. The temporal bone is subdivided into several regions. The flattened upper portion is the squamous portion of the temporal bone. Below this area and projecting anteriorly is the zygomatic process of the temporal bone, which forms the posterior portion of the zygomatic arch. Posteriorly is the mastoid portion of the temporal bone. Projecting...
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Updated: Jul 26, 2025

Author Spotlight: Development and Evaluation of a Standardized Rat Model for Calvarial Suture-Bony Composite Defects
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Cognitive Development in Single-Suture Craniosynostosis - A Systematic Review.

K Olsson1,2, J Engman1,3, D Nowinski2

  • 1Rehabilitation Medicine, Uppsala University Hospital, Uppsala, Sweden.

Developmental Neuropsychology
|June 21, 2023
PubMed
Summary
This summary is machine-generated.

Single-suture craniosynostosis (SSC) is linked to persistent cognitive development issues, affecting general and specific functions. Higher quality studies show these effects, but more research is needed on surgical impacts and long-term cognitive assessments.

Keywords:
Single-suture craniosynostosiscognitioncraniofacial abnormalitiesneurodevelopmentpsychological functions

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Area of Science:

  • Pediatric Neurosurgery
  • Developmental Psychology
  • Clinical Genetics

Background:

  • Conflicting evidence exists regarding the association between single-suture craniosynostosis (SSC) and cognitive development adversities.
  • Understanding this link is crucial for early intervention and improving long-term outcomes for affected children.

Approach:

  • A systematic literature search was performed to identify studies investigating the relationship between SSC and cognitive function.
  • Forty-eight studies were included after assessment by two independent readers to ensure rigorous data selection.
  • The review synthesized findings from diverse studies to evaluate the overall evidence for cognitive impacts.

Key Points:

  • Higher quality studies indicate small to medium, persistent effects of SSC on general and specific cognitive functions across various age groups.
  • Evidence for cognitive effects specifically related to surgical correction of SSC was limited.
  • Significant variation in study methodologies and a lack of longitudinal studies with comprehensive assessment batteries were noted.

Conclusions:

  • Single-suture craniosynostosis is associated with measurable, persistent cognitive deficits.
  • Further research employing robust longitudinal designs and broad cognitive assessments is warranted to clarify the impact of SSC and its surgical management on cognitive development.