Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Advances and perspectives in Oligo(dT) Affinity chromatography for mRNA capture: Resins, ligands and process intensification.

Journal of chromatography. A·2026
Same author

Multi-dimensional metabolic engineering and enzyme engineering in Escherichia coli for highly efficient biosynthesis of 2,5-furandicarboxylic acid.

Bioresource technology·2026
Same author

First-trimester β-hCG, PAPP-A, and NLR in relation to preeclampsia and perinatal outcomes: A case-control study.

Science progress·2026
Same author

MicroRNAs as multifaceted regulators and therapeutic targets in ulcerative colitis.

Frontiers in immunology·2026
Same author

The plant ontology of cell types.

Molecular plant·2025
Same author

Association between physical activity and knee osteoarthritis: a comprehensive systematic review and meta-analysis.

Journal of global health·2025

Related Experiment Video

Updated: May 16, 2026

Bioinspired Soft Robot with Incorporated Microelectrodes
08:24

Bioinspired Soft Robot with Incorporated Microelectrodes

Published on: February 28, 2020

Accelerated myotube formation using bioprinting technology for biosensor applications.

Xiaofeng Cui1, Guifang Gao, Yongjun Qiu

  • 1Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA. xfc.cui@gmail.com

Biotechnology Letters
|November 20, 2012
PubMed
Summary

Bioprinting precisely placed mouse myoblasts onto micro-cantilevers, forming functional myotubes in 4 days. This muscle-powered Bio-MEMS shows potential for advanced actuators and biosensors.

More Related Videos

Printing Thermoresponsive Reverse Molds for the Creation of Patterned Two-component Hydrogels for 3D Cell Culture
10:49

Printing Thermoresponsive Reverse Molds for the Creation of Patterned Two-component Hydrogels for 3D Cell Culture

Published on: July 10, 2013

Bioprinting of Cartilage and Skin Tissue Analogs Utilizing a Novel Passive Mixing Unit Technique for Bioink Precellularization
09:03

Bioprinting of Cartilage and Skin Tissue Analogs Utilizing a Novel Passive Mixing Unit Technique for Bioink Precellularization

Published on: January 3, 2018

Related Experiment Videos

Last Updated: May 16, 2026

Bioinspired Soft Robot with Incorporated Microelectrodes
08:24

Bioinspired Soft Robot with Incorporated Microelectrodes

Published on: February 28, 2020

Printing Thermoresponsive Reverse Molds for the Creation of Patterned Two-component Hydrogels for 3D Cell Culture
10:49

Printing Thermoresponsive Reverse Molds for the Creation of Patterned Two-component Hydrogels for 3D Cell Culture

Published on: July 10, 2013

Bioprinting of Cartilage and Skin Tissue Analogs Utilizing a Novel Passive Mixing Unit Technique for Bioink Precellularization
09:03

Bioprinting of Cartilage and Skin Tissue Analogs Utilizing a Novel Passive Mixing Unit Technique for Bioink Precellularization

Published on: January 3, 2018

Area of Science:

  • BioMEMS
  • Tissue Engineering
  • Cellular Mechanics

Background:

  • Muscle-powered microdevices offer potential for actuators and biosensors.
  • Functional integration of biological components with microdevices is key.
  • Bioprinting enables precise delivery of biological factors for applications like 3D tissue fabrication.

Purpose of the Study:

  • To evaluate the feasibility of precisely placing mouse myoblasts onto micro-sized cantilevers using bioprinting.
  • To assess the functional maturation and response of bioprinted myotubes.
  • To demonstrate the potential of the integrated Bio-MEMS device as a biosensor.

Main Methods:

  • Utilized bioprinting technology for precise deposition of mouse myoblasts onto micro-cantilevers.
  • Cultured printed myoblasts to assess myotube formation and maturation time.
  • Performed electrical and chemical stimulation tests on the integrated Bio-MEMS device.

Main Results:

  • Bioprinted myoblasts formed mature myotubes in 4 days, significantly faster than randomly deposited cells (14+ days).
  • Printed myotubes exhibited functional contractility and synchronous response to electrical stimulation.
  • The Bio-MEMS device demonstrated spontaneous response to chemical stimulation, indicating biosensor capability.
  • The system showed rapid recovery of contractility after chemical stimulus removal, highlighting flexibility and recyclability.

Conclusions:

  • Bioprinting enables rapid and precise fabrication of functional muscle-powered Bio-MEMS.
  • The developed system holds promise for applications in advanced actuators and sensitive biosensors.
  • The rapid maturation and responsive nature of bioprinted myotubes underscore their potential in regenerative medicine and bioelectronic devices.