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Related Concept Videos

Prodrugs01:30

Prodrugs

Prodrugs are a class of pharmaceutical compounds that undergo a biotransformation process within the body to be converted into a pharmacologically active drug. Prodrugs are designed to improve the therapeutic properties of the parent drug, such as enhancing bioavailability, increasing stability, or reducing toxicity. The concept of prodrugs revolves around modifying the chemical structure of the original drug to make it more effective or convenient for administration.
Prodrugs help overcome...
Protein-Protein Interfaces02:04

Protein-Protein Interfaces

Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a polypeptide...
Protein-protein Interfaces02:04

Protein-protein Interfaces

Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a polypeptide...
Continuing Care01:25

Continuing Care

Continuing care describes the variety of health, personal, and social services provided over a prolonged period. The need for continuing care is increasing because people are living longer. Many people do not have families or others to care for them. Continuing care is mainly for patients who are disabled, functionally dependent, or suffering from a terminal disease. It is available within institutional settings or in homes. Examples include nursing centers or facilities, assisted living,...
Preclinical Development: Overview01:28

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Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...
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A Structured Rehabilitation Protocol for Improved Multifunctional Prosthetic Control: A Case Study
06:58

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Published on: November 6, 2015

New and continuing developments at PROSITE.

Christian J A Sigrist1, Edouard de Castro, Lorenzo Cerutti

  • 1SIB Swiss Institute of Bioinformatics, Centre Médical Universitaire (CMU), 1 rue Michel Servet, 1211 Geneva 4, Switzerland. prosite-group@isb-sib.ch

Nucleic Acids Research
|November 20, 2012
PubMed
Summary
This summary is machine-generated.

The PROSITE database and its ProRule extension offer powerful tools for identifying protein domains and functional sites. Recent updates enable whole-proteome annotation and advanced filtering for biological discovery.

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Area of Science:

  • Bioinformatics
  • Proteomics
  • Molecular Biology

Background:

  • PROSITE is a database of protein families, domains, and functional sites.
  • It uses patterns and profiles for identification.
  • ProRule enhances these signatures with critical amino acid information.

Purpose of the Study:

  • To describe recent developments in PROSITE and ProRule.
  • To enable whole-proteome annotation.
  • To introduce advanced filtering options for targeted biological discovery.

Main Methods:

  • Utilizing PROSITE patterns and profiles.
  • Integrating ProRule for enhanced signature discrimination.
  • Applying new filtering options for targeted searches.

Main Results:

  • PROSITE release 20.85 includes 1308 patterns, 1039 profiles, and 1041 ProRules.
  • New developments facilitate whole-proteome annotation.
  • Filtering options enhance the power of targeted searches.

Conclusions:

  • PROSITE and ProRule are essential for protein annotation in UniProtKB/Swiss-Prot.
  • Recent advancements improve the efficiency and scope of protein signature analysis.
  • The tools support powerful biological discovery through comprehensive data analysis.