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Updated: May 16, 2026

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Biomolecular Imaging of Cellular Uptake of Nanoparticles using Multimodal Nonlinear Optical Microscopy
Published on: May 16, 2022
Bilayered Raman-intense gold nanostructures with hidden tags (BRIGHTs) for high-resolution bioimaging
Naveen Gandra1, Srikanth Singamaneni
1Department of Mechanical Engineering and Materials Science, Washington University in St. Louis, 1 Brookings Dr., St. Louis, MO 63130, USA.
Advanced Materials (Deerfield Beach, Fla.)
|November 20, 2012
Abstract:
Conventional SERS probes suffer from limited brightness and poor reproducibility and stability making them unsuitable for routine in vivo applications. A novel class of layered SERS probes is demonstrated in which individual nanostructures host electromagnetic hotspots, thus increasing brightness by more than two orders magnitude compared to conventional individual nanostructures.

