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Assaying β-amyloid Toxicity using a Transgenic C. elegans Model
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Assaying β-amyloid Toxicity using a Transgenic C. elegans Model

Published on: October 9, 2010

Light-controlled toxicity of engineered amyloid β-peptides

Christian Hoppmann1, Christian Barucker, Dorothea Lorenz

  • 1Department of Chemical Biology, Leibniz-Institut für Molekulare Pharmakologie, Berlin, Germany. choppmann@salk.edu

Chembiochem : a European Journal of Chemical Biology
|November 20, 2012
PubMed

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Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining, normally used to...