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The platelet storage capability of different plastic containers
1Department of Clinical Immunology and Blood Transfusion Service, Karolinska Hospital, Stockholm, Sweden.
Vox Sanguinis
|January 1, 1990
Summary
The oxygen diffusion capacity of blood bags directly predicts the maximum number of platelets that can be successfully stored for five days. This finding aids in selecting optimal platelet storage bags for blood banking.
Area of Science:
- Transfusion Medicine
- Biomaterials Science
- Hematology
Background:
- Platelet concentrates (PC) are crucial for treating bleeding disorders.
- Storage conditions, including blood bag material and volume, affect PC quality.
- Optimizing PC storage is essential for maintaining platelet viability and function.
Purpose of the Study:
- To evaluate the impact of different blood bag types and volumes on platelet storage.
- To determine the relationship between blood bag oxygen diffusion capacity and PC quality.
- To identify optimal blood bags for extended platelet storage.
Main Methods:
- Prepared 99 platelet apheresis concentrates from 25 donors.
- Stored PCs in four different blood bag types and volumes.
- Assessed platelet count, pH, pO2, pCO2, and lactate levels over 5 days.
- Measured oxygen diffusion capacity of each bag type.
Main Results:
- Platelet numbers ranged from 20 to 140 X 10^9 per bag.
- Oxygen diffusion capacity varied significantly among bag types.
- A strong correlation (r=0.998) was found between oxygen diffusion capacity and maximum storable platelet number.
- Maintained pH levels (6.9-7.4) were linked to aerobic metabolism and bag oxygen diffusion.
Conclusions:
- Blood bag oxygen diffusion capacity can predict the maximum platelet yield for 5-day storage.
- This allows for the selection of optimal blood bags based on their oxygen permeability.
- Further in vivo studies are needed to validate these findings.