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Related Concept Videos

Phases of Wound Repair01:28

Phases of Wound Repair

Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
Oxygen Transport in the Blood01:27

Oxygen Transport in the Blood

Hemoglobin (Hb) is a crucial molecule in the human body, consisting of four polypeptide chains, each bound to an iron-containing heme group. This unique structure enables hemoglobin to bind to oxygen, with each molecule capable of combining with four molecules of oxygen, leading to rapid and reversible oxygen loading. When fully loaded with oxygen, it is called oxyhemoglobin, while hemoglobin that has released oxygen is called reduced hemoglobin or deoxyhemoglobin. As hemoglobin binds oxygen,...
Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure01:16

Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure

Oxygen therapy has emerged as a significant tool in enhancing the quality of life for patients suffering from pulmonary arterial hypertension (PAH). While this therapy has principally been studied on patients with significant hypoxemia, this therapeutic approach helps prevent potential organ damage and can be administered in the comfort of one's home.
Oxygen therapy is vital in increasing and maintaining blood oxygen levels in PAH patients. As a result, it aids in reducing fatigue, improving...
Healing II: Complications01:24

Healing II: Complications

Complications during healing arise when tissue repair is altered by local or systemic factors. These changes involve abnormal collagen deposition, altered biomechanics, and reduced vascular supply, impairing restoration of normal structure and function.Loss of FunctionScar tissue differs significantly from the original tissue it replaces. In the skin, fibrosis lacks adnexal structures such as hair follicles, sebaceous glands, and sweat glands. Their absence reduces tactile sensitivity, impairs...
Hypoxia01:23

Hypoxia

Hypoxia is a medical condition characterized by an inadequate oxygen supply to body tissues. It typically manifests as a bluish discoloration of the skin and mucosae, especially in fair-skinned individuals, when hemoglobin (Hb) saturation drops below 75%.
Types of Hypoxia
There are four primary types of hypoxia, each resulting from a different cause:
1. Anemic hypoxia: This type occurs due to insufficient oxygen delivery caused by a lack of red blood cells (RBCs) or RBCs with abnormal or...
Oxygen Requirements and Growth Patterns01:29

Oxygen Requirements and Growth Patterns

Microorganisms exhibit diverse oxygen requirements and growth patterns driven by their metabolic strategies and environmental adaptations. Oxygen, while essential for many organisms, can also be toxic under certain conditions, shaping how microorganisms grow and survive.Oxygen Requirements of MicroorganismsMicroorganisms are classified based on their ability to use or tolerate oxygen:● Obligate aerobes like Mycobacterium tuberculosis need oxygen for energy production, as it serves as the...

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Updated: May 16, 2026

A Simplified Technique for Producing an Ischemic Wound Model
12:00

A Simplified Technique for Producing an Ischemic Wound Model

Published on: May 2, 2012

Hyperbaric oxygen and wound healing.

Sourabh Bhutani1, Guruswamy Vishwanath

  • 1Principal Medical Officer, INS Shankul, c/o Fleet Mail Office, Colaba, Mumbai, India.

Indian Journal of Plastic Surgery : Official Publication of the Association of Plastic Surgeons of India
|November 20, 2012
PubMed
Summary
This summary is machine-generated.

Hyperbaric oxygen therapy (HBOT) offers significant benefits as an adjunctive treatment for various non-healing and infected wounds. Its approved applications include diabetic ulcers, radiation injuries, and traumatic conditions, making it essential for comprehensive wound management.

Keywords:
Air embolismcompartment syndromecrush syndromedecompression sicknessdiabetes mellitusdiabetic footgas gangrenehyperbarichyperbaric medicinehyperbaric oxygen therapyhyperbaric oxygenationnecrotising fasciitisosteomyelitisosteoradionecrosisradiation injuriesradiation necrosisreperfusion injurysoft tissue infectionssurgical flapstranscutaneous oximetry

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Last Updated: May 16, 2026

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Assessment of Acute Wound Healing using the Dorsal Subcutaneous Polyvinyl Alcohol Sponge Implantation and Excisional Tail Skin Wound Models.

Published on: March 25, 2020

Area of Science:

  • Medicine
  • Therapeutics

Background:

  • Hyperbaric oxygen therapy (HBOT) involves administering 100% oxygen at pressures exceeding atmospheric levels.
  • HBOT is an established adjunctive therapy with several approved indications.

Purpose of the Study:

  • To review the established applications and benefits of HBOT in wound healing and other conditions.
  • To highlight the expanding role of HBOT in managing complex wounds.

Main Methods:

  • Review of existing studies and clinical trials on HBOT applications.
  • Analysis of HBOT's efficacy in various wound types and radiation-induced injuries.

Main Results:

  • HBOT is effective for non-healing wounds like diabetic and vascular insufficiency ulcers.
  • Approved indications include infected wounds (e.g., Fournier's gangrene), traumatic injuries, and radiation-induced conditions (e.g., osteoradionecrosis).

Conclusions:

  • HBOT is a valuable adjunctive therapy for a range of challenging wounds.
  • Increased chamber availability and evidence support considering HBOT in wound management strategies.