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Related Concept Videos

Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own EpiSCs...

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Related Experiment Video

Updated: May 16, 2026

Generation of Self-assembled Vascularized Human Skin Equivalents
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Published on: February 12, 2021

Skin substitutes: An Indian perspective.

A K Singh1, Y R Shenoy

  • 1Department of Plastic and Reconstructive surgery, CSMMU, Lucknow, India.

Indian Journal of Plastic Surgery : Official Publication of the Association of Plastic Surgeons of India
|November 20, 2012
PubMed
Summary
This summary is machine-generated.

Numerous skin substitutes exist, but no ideal option has been developed. This review examines available skin substitutes, focusing on their feasibility for developing countries like India.

Keywords:
Indiapermanent substitutesskin substitutestemporary substitute

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Area of Science:

  • Regenerative Medicine
  • Biomaterials Science
  • Wound Healing

Background:

  • Skin substitutes are crucial for treating extensive wounds and burns.
  • Current substitutes include temporary and permanent options, aiming to reduce or replace autologous skin grafts.
  • No single skin substitute has proven ideal for all clinical scenarios.

Purpose of the Study:

  • To review the diverse range of developed skin substitutes.
  • To evaluate the utility and feasibility of these substitutes, particularly in developing countries.
  • To highlight indigenous skin substitutes developed in India.

Main Methods:

  • Comprehensive literature review of existing skin substitutes.
  • Analysis of substitute characteristics, including permanence and graft requirements.
  • Assessment of clinical applicability and economic feasibility in resource-limited settings.

Main Results:

  • A wide array of skin substitutes, both temporary and permanent, have been developed globally.
  • Significant challenges remain in achieving ideal wound closure and regeneration with current substitutes.
  • Awareness and availability of advanced skin substitutes are limited in developing nations like India.

Conclusions:

  • The development of an ideal skin substitute is an ongoing challenge.
  • The selection of appropriate skin substitutes requires careful consideration of various factors.
  • There is a critical need to improve awareness, accessibility, and development of cost-effective skin substitutes for developing countries.