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A Simple and Rapid Protocol to Non-enzymatically Dissociate Fresh Human Tissues for the Analysis of Infiltrating Lymphocytes
Published on: December 6, 2014
The antigen specific composition of melanoma tumor infiltrating lymphocytes?
1Department of Hematology; Center for Cancer Immune Therapy (CCIT); University Hospital Herlev; Herlev, Denmark ; Immunology and Microbiology; Institute for International Health; University of Copenhagen, Copenhagen, Denmark.
Abstract:
Large numbers of tumor associated antigens has been characterized, but only a minor fraction of these are recognized by tumor infiltrating lymphocytes of melanoma, although these have shown the ability to recognize tumor and provide tumor regression upon adoptive transfer. Thus the peptide recognition of the majority of the CD8 tumor infiltrating lymphocytes remains to be identified.
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