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Methyl-binding DNA capture Sequencing for Patient Tissues
Published on: October 31, 2016
DNA methylation markers for breast cancer prognosis: Unmasking the immune component
Sarah Dedeurwaerder1, François Fuks
1Laboratory of Cancer Epigenetics; Université Libre de Bruxelles; Faculty of Medicine; Brussels, Belgium.
Oncoimmunology
|November 20, 2012
Abstract:
Currently, most of the prognostic and predictive gene expression signatures emerging for breast cancer concern the tumor component. In Dedeurwaerder et al. we show that DNA methylation profiling of breast tumors is a particularly sensitive means of capturing features of the immune component of breast tumors. Most importantly, correlation is observed between T-cell marker genes and breast cancer clinical outcome.
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