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Updated: May 16, 2026

Using RNA-interference to Investigate the Innate Immune Response in Mouse Macrophages
Published on: November 3, 2014
TAMable tumor-associated macrophages in response to innate RNA sensing
Tsukasa Seya1, Hiroaki Shime, Misako Matsumoto
1Department of Microbiology and Immunology; Graduate School of Medicine; Hokkaido University; Sapporo, Japan.
Abstract:
Antitumor effect of PolyI:C (a viral dsRNA analog) has been attributed to dendritic cell (DC)-maturation activity, that drives antitumor NK cells, DC cross-presentation, cytotoxic T lymphocytes and many IFN-inducible genes. According to a recent paper, tumor-infiltrating M2 macrophages are found to become an additional antitumor effector through polyI:C response.
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