Related Experiment Video
Updated: May 16, 2026
07:08
Using Optical Coherence Tomography and Optokinetic Response As Structural and Functional Visual System Readouts in Mice and Rats
Published on: January 10, 2019
Macular imaging for glaucoma using spectral-domain optical coherence tomography: a review
Jessica J Wong1, Teresa C Chen, Lucy Q Shen
1Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Glaucoma Service, Harvard Medical School, Boston, MA, USA. Jessica.J.Wong@gmail.com
Seminars in Ophthalmology
|November 21, 2012
Summary
Spectral-domain optical coherence tomography (SD-OCT) shows promise for glaucoma diagnosis using macular thickness parameters. These measurements offer diagnostic sensitivity comparable to traditional peripapillary retinal nerve fiber layer (pRNFL) assessments.
Area of Science:
- Ophthalmology
- Medical Imaging
- Glaucoma Research
Background:
- Optical coherence tomography (OCT) is crucial for glaucoma detection and monitoring, with peripapillary retinal nerve fiber layer (pRNFL) measurements historically favored.
- Earlier time-domain OCT (TD-OCT) studies limited the use of macular thickness parameters in glaucoma due to inferior diagnostic performance compared to pRNFL.
- The development of spectral-domain OCT (SD-OCT) has enhanced macular imaging capabilities, enabling better segmentation and measurement of individual retinal layers.
Purpose of the Study:
- To review recent studies investigating the diagnostic ability, reproducibility, and limitations of macular SD-OCT parameters in glaucoma.
- To assess the current clinical utility of macular SD-OCT for glaucoma diagnosis and management.
Main Methods:
- Systematic review of recent scientific literature focusing on SD-OCT macular parameters in glaucoma.
- Analysis of studies evaluating diagnostic accuracy, reproducibility, and limitations of these novel imaging parameters.
- Comparison of SD-OCT macular parameter performance against established OCT methods (TD-OCT and pRNFL).
Main Results:
- SD-OCT demonstrates superior reproducibility compared to TD-OCT for macular imaging.
- While some conflicting reports exist, the majority of studies indicate that SD-OCT macular parameters offer diagnostic sensitivity at least comparable to TD-OCT and other SD-OCT parameters.
- Recent research highlights the growing potential of SD-OCT macular imaging in glaucoma assessment.
Conclusions:
- Macular imaging using SD-OCT is a rapidly evolving area with significant potential in glaucoma diagnosis.
- SD-OCT macular parameters show comparable diagnostic sensitivity to established OCT methods, offering a valuable addition to glaucoma assessment.
- Further research is warranted to fully elucidate the role and optimize the application of SD-OCT macular parameters in clinical practice.
Related Concept Videos
01:25Glaucoma: Overview
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
01:27Open Angle Glaucoma: Treatment
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
01:28Angle Closure Glaucoma: Treatment
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...