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Updated: May 16, 2026

System for Efficacy and Cytotoxicity Screening of Inhibitors Targeting Intracellular Mycobacterium tuberculosis
Published on: April 5, 2017
Boron-containing peptidomimetics--a novel class of selective anti-tubercular drugs
Alexey S Gorovoy1, Olga V Gozhina, John S Svendsen
1Department of Chemistry, University of Tromsø, N-9037 Tromsø, Norway.
Abstract:
Medical treatment for tuberculosis is complicated nowadays by the appearance of new multiresistant strains, and therefore, new antibiotics are in great need. Here, we report the synthesis and in vitro testing of a new class of highly selective antimicrobial boron-containing peptidomimetics with compounds exhibiting activity against Mycobacterium tuberculosis at ≤5 μg/mL. The new approach developed makes it possible to synthesize variously substituted β-aminoboronic acids and their derivatives with a high level of diastereoselectivity.
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