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Updated: May 16, 2026
12:04
The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice
Published on: November 1, 2015
Drug-induced lupus erythematosus
M Pretel1, L Marquès1, A España1
1Departamento de Dermatología, Clínica Universidad de Navarra, Facultad de Medicina, Universidad de Navarra, Pamplona, España.
Actas Dermo-Sifiliograficas
|November 21, 2012
Summary
Drug-induced lupus erythematosus (DILE) mimics idiopathic lupus but arises from specific medications. Prompt diagnosis and drug withdrawal are key for DILE resolution.
Area of Science:
- Rheumatology
- Dermatology
- Clinical Immunology
Background:
- Drug-induced lupus erythematosus (DILE) presents with clinical, histological, and immunological similarities to idiopathic lupus erythematosus.
- Over 90 drugs are currently associated with DILE, with ongoing research identifying more potential triggers.
- DILE manifests in systemic, subacute cutaneous, and chronic cutaneous forms, mirroring idiopathic lupus presentations.
Purpose of the Study:
- To highlight the diagnostic importance of Drug-induced lupus erythematosus (DILE).
- To emphasize the relationship between drug intake and lupus-like symptoms.
- To underscore the therapeutic significance of drug withdrawal in managing DILE.
Main Methods:
- Review of clinical, histological, and immunological features of DILE.
- Compilation of drugs associated with DILE development.
- Analysis of DILE presentation forms (systemic, cutaneous).
Main Results:
- DILE shares significant overlap with idiopathic lupus erythematosus.
- A broad spectrum of over 90 drugs can induce lupus-like syndromes.
- DILE encompasses systemic, subacute cutaneous, and chronic cutaneous manifestations.
Conclusions:
- Accurate diagnosis of DILE is crucial for effective patient management.
- Withdrawal of the causative agent is the primary treatment for DILE.
- Understanding the link between drugs and lupus-like symptoms aids in prompt resolution.
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