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Real Time Measurements of Membrane Protein:Receptor Interactions Using Surface Plasmon Resonance (SPR)
Published on: November 29, 2014
Fabry-Pérot-based surface plasmon resonance sensors
Feng Xiao1, Guangyuan Li, Kamal Alameh
1Electron Science Research Institute, Edith Cowan University, Joondalup 6027, Australia. f.xiao@ecu.edu.au
Abstract:
A new sensing approach based on the use of an optical Fabry-Pérot (FP) cavity in conjunction with surface plasmon resonance (SPR) is proposed and theoretically investigated. The impact of the SPR on the intensity and phase response of the proposed sensor structure is evaluated using a modified FP model that takes into account the SPR effect. Compared to the conventional optical-phase-detection-based Kretschmann configuration, the proposed sensing approach requires only the measurement of the output power spectrum over a narrow wavelength span of several nanometers to evaluate the phase responses of the sensor, making it more attractive for practical high-sensitivity sensing applications.
