Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 16, 2026

Three Laboratory Procedures for Assessing Different Manifestations of Impulsivity in Rats
09:12

Three Laboratory Procedures for Assessing Different Manifestations of Impulsivity in Rats

Published on: March 17, 2019

Haloperidol modulates midbrain-prefrontal functional connectivity in the rat brain.

Natalia Gass1, Adam James Schwarz, Alexander Sartorius

  • 1Department of Neuroimaging, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Germany.

European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology
|November 21, 2012
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Kynurenine pathway profiles as markers of ketamine response in treatment-resistant depression.

Brain, behavior, and immunity·2026
Same author

Baseline inflammatory profiles in moderate-to-severe depression and differential response to intermittent theta-burst stimulation.

Progress in neuro-psychopharmacology & biological psychiatry·2026
Same author

Electroconvulsive therapy in Germany: a nationwide multilevel analysis of determinants, regional patterns, and institutional variation.

European archives of psychiatry and clinical neuroscience·2026
Same author

A unified voice for evidence-based psychiatry: a global response to the WHO guidance on ECT.

European archives of psychiatry and clinical neuroscience·2026
Same author

Just a caffeine-blocker? Questioning new proposed core mechanisms of ECT.

Brain stimulation·2026
Same author

Joint statement by the World Psychiatric Association, the American Psychiatric Association, the European Psychiatric Association, and the Global Expert Task Force on ECT on the portrayal of electroconvulsive therapy in the WHO Guidance on Mental Health Policy and Strategic Action Plans.

The lancet. Psychiatry·2026

Haloperidol, a dopamine D₂ receptor antagonist, alters functional brain connectivity in rats. This antipsychotic medication reduced connectivity in key dopamine pathways, potentially explaining its therapeutic and side effects.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Psychiatry

Background:

  • Dopamine D₂ receptor antagonists are primary treatments for schizophrenia's positive symptoms.
  • Abnormal dopaminergic neurotransmission is linked to psychosis.
  • The impact of D₂ antagonists on functional brain connectivity remains unexamined.

Purpose of the Study:

  • To investigate the effects of haloperidol, a D₂ antagonist, on functional connectivity within dopaminergic circuits.
  • To explore how haloperidol modulates interactions between brain regions involved in dopamine signaling.

Main Methods:

  • Ten male Sprague-Dawley rats received haloperidol (1 mg/kg) or saline, with a one-week washout period.
  • Resting-state functional magnetic resonance imaging (fMRI) was used to acquire brain data 20 minutes post-injection.
Keywords:
AntagonismDopamineFunctional connectivityHaloperidolRatSchizophrenia

More Related Videos

Acquisition of Resting-State Functional Magnetic Resonance Imaging Data in the Rat
12:41

Acquisition of Resting-State Functional Magnetic Resonance Imaging Data in the Rat

Published on: August 28, 2021

Acute In Vivo Electrophysiological Recordings of Local Field Potentials and Multi-unit Activity from the Hyperdirect Pathway in Anesthetized Rats
10:46

Acute In Vivo Electrophysiological Recordings of Local Field Potentials and Multi-unit Activity from the Hyperdirect Pathway in Anesthetized Rats

Published on: June 22, 2017

Related Experiment Videos

Last Updated: May 16, 2026

Three Laboratory Procedures for Assessing Different Manifestations of Impulsivity in Rats
09:12

Three Laboratory Procedures for Assessing Different Manifestations of Impulsivity in Rats

Published on: March 17, 2019

Acquisition of Resting-State Functional Magnetic Resonance Imaging Data in the Rat
12:41

Acquisition of Resting-State Functional Magnetic Resonance Imaging Data in the Rat

Published on: August 28, 2021

Acute In Vivo Electrophysiological Recordings of Local Field Potentials and Multi-unit Activity from the Hyperdirect Pathway in Anesthetized Rats
10:46

Acute In Vivo Electrophysiological Recordings of Local Field Potentials and Multi-unit Activity from the Hyperdirect Pathway in Anesthetized Rats

Published on: June 22, 2017

  • Connectivity analyses included correlation between 44 regions of interest and seed-based connectivity mapping.

    • Main Results:

    • Haloperidol significantly reduced functional connectivity between the substantia nigra and multiple brain areas, including the cingulate cortex, prefrontal cortex, hippocampus, ventral pallidum, and motor cortex.
    • Focal changes in connectivity were strongly associated with ascending dopamine projections.
    • Reduced midbrain-medial prefrontal cortex and midbrain-hippocampus connectivity were observed, alongside decreased substantia nigra-motor cortex coupling.

    Conclusions:

    • Haloperidol modulates functional connectivity in dopaminergic circuits, with observed changes potentially correlating to therapeutic effects and side effects like dyskinesia.
    • These findings provide insights into the neural circuits affected by antipsychotics.
    • Understanding these modulated circuits could inform the development of novel therapeutic strategies for psychiatric disorders.