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Related Concept Videos

Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
Inflammatory Bowel Disease II: Ulcerative Colitis01:20

Inflammatory Bowel Disease II: Ulcerative Colitis

Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Drugs for Treatment of Ulcerative Colitis in IBD01:29

Drugs for Treatment of Ulcerative Colitis in IBD

Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide generation. 
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the colonic...

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Related Experiment Video

Updated: May 16, 2026

Murine Distal Colostomy, A Novel Model of Diversion Colitis in C57BL/6 Mice
08:20

Murine Distal Colostomy, A Novel Model of Diversion Colitis in C57BL/6 Mice

Published on: July 12, 2018

Decreasing colectomy rates for ulcerative colitis: a population-based time trend study.

Gilaad G Kaplan1, Cynthia H Seow, Subrata Ghosh

  • 1Inflammatory Bowel Disease Clinic, University of Calgary, Calgary, Alberta, Canada. ggkaplan@ucalgary.ca

The American Journal of Gastroenterology
|November 21, 2012
PubMed
Summary
This summary is machine-generated.

Colectomy rates for ulcerative colitis (UC) decreased significantly for elective procedures between 1997 and 2009, while emergent colectomy rates remained stable. Increased use of immunosuppressive medications correlated with these trends.

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Last Updated: May 16, 2026

Murine Distal Colostomy, A Novel Model of Diversion Colitis in C57BL/6 Mice
08:20

Murine Distal Colostomy, A Novel Model of Diversion Colitis in C57BL/6 Mice

Published on: July 12, 2018

Area of Science:

  • Gastroenterology
  • Surgical Outcomes
  • Health Services Research

Background:

  • Colectomy rates for ulcerative colitis (UC) show considerable variability in reported data.
  • Understanding temporal trends in colectomy is crucial for managing UC.
  • Stratification by indication (emergent vs. elective) is needed to interpret these trends.

Purpose of the Study:

  • To assess temporal trends in colectomy rates for ulcerative colitis (UC) from 1997 to 2009.
  • To differentiate trends between emergent and elective colectomies.
  • To evaluate the impact of medical management and drug utilization on colectomy rates.

Main Methods:

  • Retrospective review of adult patients hospitalized for UC flares (1997-2009).
  • Linear regression to determine Average Annual Percent Change (AAPC) in surgical rates.
  • Logistic regression to compare patient outcomes, colectomy indications, and drug utilization trends.

Main Results:

  • Elective colectomy rates significantly decreased (AAPC: -7.4%).
  • Emergent colectomy rates remained stable (AAPC: -1.4%).
  • Use of azathioprine/6-mercaptopurine and infliximab increased; patients responding to medical management had reduced colectomy odds.

Conclusions:

  • Elective colectomy rates in UC patients declined significantly from 1997 to 2009.
  • Stable emergent colectomy rates may indicate rapid disease progression.
  • Increased use of purine anti-metabolites and biologics likely contributed to reduced elective colectomy rates.