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Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions
Published on: July 17, 2020
A new ascochlorin derivative from Cylindrocarpon sp. FKI-4602
Mio Kawaguchi1, Takashi Fukuda, Ryuji Uchida
1Graduate School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan.
Abstract:
Cylindrol A₅, a new ascochlorin congener, was isolated along with 14 known compounds from the culture broth of Cylindrocarpon sp. FKI-4602 by solvent extraction, octadecylsilane column chromatography and HPLC. The structure of cylindrol A₅ was elucidated by spectral analyses, including NMR. The compound has an ascochlorin skeleton consisting of a resorcin aldehyde and a cyclohexanone moieties. Cylindrol A₅ showed moderate antimicrobial activity against Bacillus subtilis, Kocuria rhizophila, Mycobacterium smegmatis and Acholeplasma laidlawii. The biosynthetic pathway to cylindrol A₅ was deduced from the 14 isolated metabolites of the fungal strain.

