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Relationship between mean platelet volume and mitral annular calcification

Ercan Varol1, Fatih Aksoy, Mehmet Ozaydin

  • 1Department of Cardiology, Suleyman Demirel University, Isparta, Turkey. drercanvarol@yahoo.com

Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis
|November 22, 2012
PubMed

Insights

Mitral annular calcification (MAC) is linked to increased platelet activation, indicated by higher mean platelet volume (MPV) and platelet distribution width (PDW). These markers are independently associated with MAC, suggesting a role in cardiovascular disease risk.

Area of Science:

  • Cardiovascular Medicine
  • Hematology
  • Biomarkers

Background:

  • Mitral annular calcification (MAC) is a significant cardiovascular disease risk factor, sharing common risk factors with atherosclerosis.
  • MAC is associated with increased risks of coronary artery disease, heart failure, and stroke.
  • Platelet activation plays a crucial role in atherothrombosis and cardiovascular events.

Purpose of the Study:

  • To investigate the association between mean platelet volume (MPV), a marker of platelet activation, and mitral annular calcification (MAC).
  • To compare MPV and other platelet indices in patients with MAC versus a control group.
  • To determine if MPV and platelet distribution width (PDW) are independent predictors of MAC.

Main Methods:

  • A case-control study involving 101 patients with MAC and 55 age, sex, and BMI-matched controls without MAC.
  • Measurement of platelet indices, including MPV and PDW, in all study participants.
  • Statistical analysis to compare platelet indices between groups and assess correlations and independent associations with MAC.

Main Results:

  • Patients with MAC exhibited significantly higher MPV (8.9 ± 0.8 fl vs. 8.0 ± 0.9 fl) and PDW (15.8 ± 1.3% vs. 15.0 ± 1.3%) compared to controls (P < 0.001 for both).
  • MPV showed a positive correlation with MAC severity (r=0.47, P<0.001), atrial fibrillation, and left atrial size, and a negative correlation with platelet count.
  • Both MPV (OR 3.89) and PDW (OR 2.27) were independently associated with MAC, indicating their predictive value.

Conclusions:

  • Mean platelet volume (MPV) and platelet distribution width (PDW) are significantly elevated in patients with mitral annular calcification (MAC).
  • Elevated MPV and PDW are independently associated with MAC, suggesting their potential as biomarkers for cardiovascular risk.
  • These findings highlight the role of platelet activation in the pathophysiology of MAC and related cardiovascular disorders.

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