Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Allergic Reactions02:06

Allergic Reactions

Overview
Allergic Drug Reactions01:27

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing numerous...
Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...
Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Skinspan<sup>TM</sup>: A Healthy Longevity Framework for Skin Aging.

Mayo Clinic proceedings·2025
Same author

Conjunctival Plaques Leading to Diagnosis of Chronic Lymphocytic Leukemia.

Ophthalmology·2025
Same author

Recurrent Cellulitis in the Intergluteal Area in a Pediatric Patient with Klippel-Trenaunay Syndrome.

Rhode Island medical journal (2013)·2025
Same author

Evaluating Copositivity Patterns in Fragrance/Botanical Patch Testing through Hierarchical Clustering and Network Analysis.

Dermatitis : contact, atopic, occupational, drug·2025
Same author

Trends in Patch Test Results With the Mayo Clinic Extended Standard Series: A 14-Year Retrospective Review (2010-2023).

Dermatitis : contact, atopic, occupational, drug·2025
Same author

Central centrifugal cicatricial alopecia: retrospective case-control study of 54 patients from a tertiary care center.

International journal of women's dermatology·2025
Same journal

The Toxin of the Year: Airborne PM<sub>2.5</sub>.

Dermatitis : contact, atopic, occupational, drug·2026
Same journal

Eyelid Dermatitis: A 5-Year Retrospective Review from a Metropolitan Contact Dermatitis Clinic.

Dermatitis : contact, atopic, occupational, drug·2026
Same journal

<i>Letter:</i> Anogenital Dermatitis Rarely Occurs in Isolation: Disease Distribution and Delays in Patch Testing.

Dermatitis : contact, atopic, occupational, drug·2026
Same journal

Practical Techniques: Photopatch Testing.

Dermatitis : contact, atopic, occupational, drug·2026
Same journal

Assessment and Clinical Management of Patients With Atopic Dermatitis Undergoing Patch Testing: Recommendations From an International Electronic Delphi Consensus.

Dermatitis : contact, atopic, occupational, drug·2026
Same journal

Digital Image Superimposition for Identifying Delayed Patch Test Reactions: A Clinical Pearl.

Dermatitis : contact, atopic, occupational, drug·2026
See all related articles

Related Experiment Video

Updated: May 16, 2026

Humanized Mediator Release Assay as a Read-Out for Allergen Potency
10:22

Humanized Mediator Release Assay as a Read-Out for Allergen Potency

Published on: June 29, 2021

Patch testing with textile allergens: the mayo clinic experience.

Ashley B Wentworth1, Donna M Richardson, Mark D P Davis

  • 1College of Medicine, Mayo Medical School, Mayo Clinic, Rochester, MN 55905, USA.

Dermatitis : Contact, Atopic, Occupational, Drug
|November 22, 2012
PubMed
Summary
This summary is machine-generated.

Allergic contact dermatitis from textiles is rising. A textile patch test series, when added to standard testing, significantly improves the diagnosis of textile-related allergies.

More Related Videos

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber
08:47

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber

Published on: March 3, 2023

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation
08:02

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation

Published on: March 24, 2023

Related Experiment Videos

Last Updated: May 16, 2026

Humanized Mediator Release Assay as a Read-Out for Allergen Potency
10:22

Humanized Mediator Release Assay as a Read-Out for Allergen Potency

Published on: June 29, 2021

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber
08:47

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber

Published on: March 3, 2023

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation
08:02

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation

Published on: March 24, 2023

Area of Science:

  • Dermatology
  • Allergology
  • Contact Dermatitis

Background:

  • Allergic contact dermatitis (ACD) from textile dyes and resins is a growing concern.
  • Increased recognition of textile-related ACD necessitates improved diagnostic approaches.

Purpose of the Study:

  • To review patch testing results with a textile series at our institution.
  • To compare findings with existing literature on textile allergies.

Main Methods:

  • Retrospective review of 671 patients patch tested with a textile series (42 dyes/resins) from 2000-2011.
  • Patients were also tested with standard patch test series.
  • Analysis of allergic and irritant reactions to textile allergens.

Main Results:

  • 32.6% of patients showed allergic reactions to textile dyes/resins; 10.6% had irritant reactions.
  • Most common allergens: Disperse Blue 106 (8.3%), Disperse Blue 124 (8.0%), Melamine formaldehyde (8.0%).
  • P-phenylenediamine, a traditional screening allergen, caused positive reactions in 5.8% of patients tested with the standard series.

Conclusions:

  • Adding a textile-specific series to standard patch testing enhances the detection of textile allergies.
  • The textile series is crucial for accurate diagnosis in patients with suspected textile-related ACD.