Recurrent Cellulitis in the Intergluteal Area in a Pediatric Patient with Klippel-Trenaunay Syndrome

Klippel-Trenaunay syndrome (KTS) is a rare congenital vascular disorder associated with somatic mutations in the PIK3CA gene, characterized classically by a triad of capillary malformations, venous malformations, and soft tissue and bone hypertrophy. While KTS commonly involves a single lower extremity, we present an atypical pediatric case featuring extensive venolymphatic malformation of the intergluteal region. This uncommon anatomical localization predisposed the patient to recurrent episodes of cellulitis, significantly complicating clinical management. This case underscores the importance of recognizing atypical presentations of KTS and the heightened susceptibility to recurrent infections, such as cellulitis, which may significantly impact morbidity and patient care.