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Updated: May 16, 2026
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Induction and Monitoring of Adoptive Delayed-Type Hypersensitivity in Rats
Published on: October 1, 2007
Immediate and delayed hypersensitivity to systemic corticosteroids: 2 case reports
Lauren Laberge1, Melanie Pratt
1University of Ottawa, Ottawa, Ontario, Canada. lfratesi@hotmail.com
Dermatitis : Contact, Atopic, Occupational, Drug
|November 22, 2012
Summary
Corticosteroid allergy can cause immediate (Type I) and delayed (Type IV) reactions. Recognizing these allergies is crucial for patients experiencing worsening anaphylactic symptoms after corticosteroid administration.
Area of Science:
- Allergy and Immunology
- Dermatology
- Pharmacology
Background:
- Immediate (Type I) and delayed (Type IV) hypersensitivity reactions to systemic corticosteroids are documented.
- Type I reactions are rare, while Type IV reactions are more common.
Observation:
- A patient experienced anaphylactoid symptoms (pruritus, hives) within 30 minutes of parenteral corticosteroids, followed by respiratory deterioration and eczematous dermatitis 24 hours later.
- Intradermal testing confirmed a Type I reaction to multiple corticosteroid preparations.
- Another patient developed urticarial lesions immediately after intralesional triamcinolone, with testing confirming a Type I allergy.
Findings:
- Confirmed Type I anaphylactoid reaction to parenteral corticosteroids.
- Clinical presentation consistent with Type IV delayed hypersensitivity to corticosteroids.
- Positive intradermal testing confirmed Type I allergy to triamcinolone.
Implications:
- Consider corticosteroid allergy in patients with unexplained anaphylactic symptoms post-administration.
- Differentiating between Type I and Type IV hypersensitivity reactions is important for diagnosis and management.
- Awareness of corticosteroid allergies can improve patient safety and treatment outcomes.
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