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Published on: February 7, 2019
Light-induced stereospecific intramolecular [2+2]-cycloaddition of atropisomeric 3,4-dihydro-2-pyridones
Elango Kumarasamy1, J Sivaguru
1Department of Chemistry and Biochemistry, North Dakota State University, Fargo, North Dakota 58108, USA.
Abstract:
Atropisomeric 3,4-dihydro-2-pyridones undergo stereospecific [2+2]-photocycloaddition in solution with high stereoselectivity (ee > 98% and de > 96%) in the product. The chiral transfer during phototransformation was rationalized based on the stability/reactivity of the biradical.
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