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[Iatrogenic Cushing syndrome in infants. Report of a case with dwarfism]
M Petrus1, J C Netter, F Rance
1Service de Pédiatrie, Centre Hospitalier, TARBES.
Insights
Iatrogenic Cushing syndrome and severe dwarfism occurred in an infant due to prenatal and postnatal corticosteroid exposure. Treatment with hydrocortisone led to a favorable outcome, despite a co-existing food allergy.
Area of Science:
- Pediatrics
- Endocrinology
- Pharmacology
Background:
- Corticosteroid exposure during pregnancy and infancy can lead to significant health issues.
- Iatrogenic Cushing syndrome is a rare condition caused by external corticosteroid administration.
- Infantile dwarfism can be a consequence of prolonged corticosteroid exposure.
Abstract:
We report a case of iatrogenic Cushing syndrome with dwarfism (-6 SD) in an eight-month-old infant. The respective role of exposure to corticosteroids in utero (the mother took 30 mg prednisolone per day throughout pregnancy) and postnatally (oral prednisolone, prednisolone in breast milk, and betamethasone cream) is discussed. Two other features are pointed out, i.e. presence of a food allergy and favorable outcome under hydrocortisone therapy.