Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hypertension and Regulation of Blood Pressure01:18

Hypertension and Regulation of Blood Pressure

Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
Hypertension I: Introduction01:28

Hypertension I: Introduction

Hypertension is a widespread, long-term medical condition where blood pressure in the arteries remains elevated. It is characterized by systolic blood pressure readings of 130 mm Hg or above or diastolic blood pressure (DBP) readings of 80 mm Hg or higher. Unmanaged hypertension poses significant health risks, making the distinction between primary (or essential) hypertension and secondary hypertension crucial, as their management and implications vary.Primary HypertensionPrimary hypertension,...
Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
Hypertension IV: Drug Therapy and Lifestyle Modifications01:28

Hypertension IV: Drug Therapy and Lifestyle Modifications

Multiple classes of antihypertensive medications are employed in treating hypertension. The most commonly recommended first-line treatments include:Thiazide Diuretics, such as chlorthalidone, increase sodium and water excretion from the body, reducing blood volume and blood pressure.Angiotensin-converting enzyme inhibitors, like lisinopril, block the conversion of angiotensin I to II, a potent vasoconstrictor lowering blood pressure.Angiotensin II Receptor Blockers (ARBs) prevent angiotensin II...
Heart Failure Drugs: Inhibitors of Renin-Angiotensin System01:26

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System

The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

L-Serine for GRIA3 and GRIN2B-related neurodevelopmental disorders.

Brain : a journal of neurology·2026
Same author

Investigation of Renal Tissue Deposition of the Calcineurin Inhibitors Voclosporin, Cyclosporine and Tacrolimus Using MALDI-MSI Imaging.

Pharmaceutical research·2026
Same author

Contribution of genetic variants to nephrolithiasis.

Kidney international·2025
Same author

PET imaging of mitochondrial complex-I in the adenine-induced tubulointerstitial nephropathy mouse model using [<sup>18</sup>F]BCPP-BF.

EJNMMI radiopharmacy and chemistry·2025
Same author

Promoting and Supporting Positive Conversations and Knowledge Mobilisation About Organ Donation in NHS Staff: a Hashtag "#" Series of Projects.

Transplant international : official journal of the European Society for Organ Transplantation·2025
Same author

Team science training for clinical and translational Scientists: An assessment of effectiveness.

Journal of clinical and translational science·2025

Related Experiment Video

Updated: May 16, 2026

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion
08:35

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion

Published on: May 26, 2022

Truly resistant hypertension?

Cate Goodlad1, Robert Unwin, David Reaich

  • 1Department of Nephrology, North Middlesex Hospital, London, UK. categoodlad@yahoo.co.uk

BMJ Case Reports
|November 22, 2012
PubMed
Summary
This summary is machine-generated.

A young man experienced severe, resistant hypertension leading to organ damage and sudden death. Despite investigations and nephrectomy, the cause of his persistent high blood pressure remained elusive.

More Related Videos

Improved Home Blood Pressure Control by CT-guided Ozone-mediated Renal Denervation for Patients with Resistant Hypertension
04:37

Improved Home Blood Pressure Control by CT-guided Ozone-mediated Renal Denervation for Patients with Resistant Hypertension

Published on: June 6, 2025

Related Experiment Videos

Last Updated: May 16, 2026

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion
08:35

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion

Published on: May 26, 2022

Improved Home Blood Pressure Control by CT-guided Ozone-mediated Renal Denervation for Patients with Resistant Hypertension
04:37

Improved Home Blood Pressure Control by CT-guided Ozone-mediated Renal Denervation for Patients with Resistant Hypertension

Published on: June 6, 2025

Area of Science:

  • Nephrology
  • Cardiology
  • Hypertension Research

Background:

  • Severe hypertension can lead to significant neurological and cardiovascular end-organ damage.
  • Resistant hypertension poses a major clinical challenge in patient management.

Purpose of the Study:

  • To investigate the cause of severe, resistant hypertension in a young male patient.
  • To explore the potential role of renal abnormalities in severe hypertension.

Main Methods:

  • Case report detailing clinical presentation, investigations, and management.
  • Diagnostic workup included imaging for renal abnormalities and assessment for secondary causes of hypertension.
  • Treatment involved aggressive antihypertensive pharmacotherapy and surgical intervention (nephrectomy).

Main Results:

  • The patient presented with severe hypertension, neurological, and cardiovascular damage.
  • Investigations revealed a small right kidney and a left renal artery aneurysm.
  • Hypertension persisted post-nephrectomy, and the aneurysm was not implicated as the cause.
  • Despite maximal medical therapy, sustained hypertension led to left ventricular hypertrophy and a fatal outcome.

Conclusions:

  • This case highlights the diagnostic challenges in severe, resistant hypertension.
  • Even with identified renal abnormalities, the etiology of hypertension may remain unclear.
  • Resistant hypertension carries a poor prognosis, emphasizing the need for further research into its underlying mechanisms.