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Interleukin-2 treatment of tumor patients can expand regulatory T cells

Marc Beyer1

  • 1Genomics and Immunoregulation; LIMES-Institute; University of Bonn; Bonn, Germany.

Oncoimmunology
|November 22, 2012
PubMed

Augmented numbers of regulatory T cells contribute to the overall immunosuppression in tumor patients. Interleukin-2 has been widely used in the clinics in anticancer therapy, yet evidence has accumulated that the major drawback, limiting clinical efficacy, is the expansion of regulatory T cells, which aggravates immunosuppression.

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