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Updated: May 16, 2026

Isotropic Light-Sheet Microscopy and Automated Cell Lineage Analyses to Catalogue Caenorhabditis elegans Embryogenesis with Subcellular Resolution
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WDDD: Worm Developmental Dynamics Database.

Koji Kyoda1, Eru Adachi, Eriko Masuda

  • 1Laboratory for Developmental Dynamics, RIKEN Quantitative Biology Center, Kobe 650-0047, Japan.

Nucleic Acids Research
|November 23, 2012
PubMed
Summary
This summary is machine-generated.

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This study introduces the Worm Developmental Dynamics Database, offering quantitative data on cell division in C. elegans embryos with gene silencing. This resource aids in understanding developmental mechanisms through computational analysis.

Area of Science:

  • Developmental biology
  • Cell biology
  • Genetics

Background:

  • Cellular dynamics and gene expression are crucial during animal development.
  • Understanding molecular mechanisms requires quantitative data on morphological changes under gene perturbations.

Purpose of the Study:

  • To create a comprehensive database of quantitative cell division dynamics in early Caenorhabditis elegans embryos.
  • To provide a resource for studying the effects of single-gene silencing on embryonic development.

Main Methods:

  • Developed the Worm Developmental Dynamics Database (http://so.qbic.riken.jp/wddd/).
  • Collected quantitative data on nuclear region outlines and their dynamics over time.
  • Utilized RNA-mediated interference (RNAi) to silence individual genes in C. elegans embryos.

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Last Updated: May 16, 2026

Isotropic Light-Sheet Microscopy and Automated Cell Lineage Analyses to Catalogue Caenorhabditis elegans Embryogenesis with Subcellular Resolution
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Published on: June 6, 2019

C. elegans Tracking and Behavioral Measurement
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A Microfluidic Platform for Longitudinal Imaging in Caenorhabditis elegans
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  • Acquired four-dimensional differential interference contrast microscopy images.

    • Main Results:

    • The database contains 50 data sets for wild-type embryos and 136 for RNAi-treated embryos.
    • Data covers 72 essential embryonic genes on chromosome III.
    • Quantitative data (3D coordinates of nuclear outlines) and corresponding microscopy images are available.

    Conclusions:

    • The database offers a rich resource for investigating developmental mechanisms.
    • Enables the development of computational methods for new insights into development.
    • Provides easy access for experimental biologists to quantitative data and images for synchronous viewing.