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Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

Improved correction for gradient nonlinearity effects in diffusion-weighted imaging.

Ek T Tan¹, Luca Marinelli, Zachary W Slavens

¹GE Global Research, Niskayuna, New York 12309, USA. ek.tan@ge.com

Journal of Magnetic Resonance Imaging : JMRI

|November 23, 2012

Summary

This summary is machine-generated.

Gradient nonlinearity correction (GNC) in diffusion-weighted imaging (DWI) significantly improves apparent diffusion coefficient (ADC) accuracy. This enhanced method reduces spatial variance and interscanner reproducibility errors in MRI scans.

Keywords:

cancer imaging diffusion weighted imaging gradient nonlinearity

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Area of Science:

Magnetic Resonance Imaging
Diffusion-Weighted Imaging
Medical Physics

Background:

Gradient nonlinearity (GN) effects in diffusion-weighted imaging (DWI) cause spatially varying apparent diffusion coefficient (ADC) measurements.
These effects are particularly significant in large field-of-view imaging and can be confounded by acquisition-related distortions.

Purpose of the Study:

To develop and evaluate an improved method for correcting gradient nonlinearity (GN) effects in DWI.
To assess the impact of enhanced GN correction (GNC) on the accuracy and reproducibility of ADC measurements.

Main Methods:

Evaluated the effect of more accurate gradient field maps on GNC of ADC.
Compared GN effects using simulations and phantom imaging across different MRI systems and bore sizes.
Applied various correction methods to quantify spatial variance and interscanner reproducibility errors.

Main Results:

A seventh-order GNC improved ADC accuracy by 1% compared to conventional methods.
Combined GNC with dual-spin-echo and retrospective concomitant field correction reduced spatial variance ADC error to 1.8% in both 55 cm and 60 cm bores.
Interscanner reproducibility error for ADC was reduced from 5.8% to 0.15% at isocenter and from 10% to 0.63% at 11 cm from isocenter.

Conclusions:

Gradient nonlinearity correction (GNC) in DWI substantially enhances the spatial accuracy of ADC measurements.
The implemented GNC method significantly improves interscanner reproducibility of ADC values, leading to more reliable imaging results.