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5-HT1A receptor function in depression: effect of chronic amitriptyline treatment
K P Lesch1, J Disselkamp-Tietze, A Schmidtke
1Department of Psychiatry, University of Würzburg, Federal Republic of Germany.
Journal of Neural Transmission. General Section
|January 1, 1990
Abstract:
Hypothermic responses to 5-HT1A receptor activation by the selective ligand ipsapirone (IPS) were attenuated in depressed patients as compared to controls. Chronic treatment with amitriptyline (AMI) further impaired 5-HT1A-mediated hypothermia. The results indicate a subsensitive (presynaptic) 5-HT1A receptor and/or a defective post-receptor signalling pathway in depression and are consistent with the hypothesis that 5-HT1A receptors are down-regulated during AMI treatment.