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In vivo solid-phase microextraction for tissue bioanalysis.

Erasmus Cudjoe1, Barbara Bojko, Paul Togunde

  • 1Department of Chemistry, University of Waterloo, 200 University Avenue West, Waterloo, Ontario, N2L 3G1, Canada.

Bioanalysis
|November 24, 2012
PubMed
Summary
This summary is machine-generated.

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In vivo solid-phase microextraction (SPME) offers advantages over traditional methods for analyzing compounds in biological tissues. This review highlights recent trends and applications of in vivo SPME in tissue bioanalysis.

Area of Science:

  • Bioanalytical Chemistry
  • Pharmacokinetics
  • Metabolomics

Background:

  • Traditional in vitro/ex vivo bioanalytical methods face challenges in representing biological systems.
  • In vivo microsampling methods are gaining interest due to their advantages.
  • In vivo solid-phase microextraction (SPME) is a diffusion-based technique successfully applied to biological systems.

Purpose of the Study:

  • To review recent trends in tissue bioanalysis using in vivo SPME.
  • To discuss various bioapplications and strategies for improving sensitivity.
  • To describe current in vivo SPME devices and novel biocompatible coatings.

Main Methods:

  • Review of recent literature on in vivo SPME applications in tissue bioanalysis.
  • Description of in vivo SPME devices and their use in different biological systems.

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  • Evaluation of biocompatible coatings for enhanced metabolite coverage.

    • Main Results:

    • In vivo SPME has been successfully applied to various biological systems for tissue bioanalysis.
    • Strategies for enhancing sensitivity in in vivo SPME are discussed.
    • New biocompatible coatings show potential for improved metabolite coverage in untargeted metabolomics.

    Conclusions:

    • In vivo SPME is a valuable tool for tissue bioanalysis, offering advantages over conventional methods.
    • Further development of in vivo SPME devices and materials can improve sensitivity and metabolite profiling.
    • This technique holds promise for advancing untargeted metabolomics studies.