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Published on: April 27, 2021
A primer for best practices in tissue preparation for bioanalysis
Christopher J Kemper1, Lee Koetzner, Michael Koleto
1Pharma Navigators, LLC, 25 Dix Lane, Lawrenceville, NJ 08648, USA. chris_kemper@pharmanavigatorsllc.com
Bioanalysis
|November 24, 2012
Summary
This guide offers best practices for tissue analysis in drug development. It covers study design, sample handling, and quality control for efficient and accurate results.
Area of Science:
- Pharmacology and Toxicology
- Analytical Chemistry
- Biomarker Discovery
Background:
- Tissue analysis is crucial for drug development, impacting biomarker and metabolite studies.
- Recent advancements in technology have significantly improved the efficiency, precision, and accuracy of tissue sample handling.
Purpose of the Study:
- To provide a foundational guide on best practices for tissue analysis.
- To offer practical tutorials on laboratory operations and study design principles.
- To assist analytical scientists in initiating tissue analysis with minimal resource investment.
Main Methods:
- Discussion of critical factors in study design.
- Guidance on tissue acquisition, extraction, and sample processing.
- Recommendations for creating standards and quality controls (QCs).
Main Results:
- Improved efficiency and accuracy in tissue sample analysis.
- Practical advice for scientists transitioning to tissue analysis.
- Streamlined approach to minimize time, labor, and cost.
Conclusions:
- Adherence to best practices enhances the reliability of tissue analysis in drug development.
- This primer equips scientists with the knowledge to conduct tissue analyses effectively.
- Optimized tissue analysis contributes to a more efficient drug development pipeline.
