Ag nanorod based surface-enhanced Raman spectroscopy applied to bioanalytical sensing

Area of Science:

• Nanotechnology
• Biomedical Engineering
• Analytical Chemistry

Background:

• Substrate nanofabrication has advanced, enabling uniform and reproducible large-area Surface-Enhanced Raman Spectroscopy (SERS)-active substrates.
• Silver nanorod arrays exhibit high signal enhancement, making them promising for sensitive detection applications.

Purpose of the Study:

• To review nanostructured substrates for SERS applications.
• To highlight the fabrication of silver nanorod arrays using oblique angle vapor deposition (OAD).
• To summarize recent applications of these substrates in clinical diagnostics and biomedical fields.

Main Methods:

• Fabrication of silver nanorod arrays via oblique angle vapor deposition (OAD).
• Characterization of morphological and physical properties of the nanostructures.
• Investigation of SERS-based detection of biological agents (bacteria, viruses) and biomolecules (oligonucleotides).

Main Results:

• Developed uniform, reproducible, large-area SERS-active silver nanorod arrays with high signal enhancement.
• Demonstrated robust platform for rapid detection and identification of pathogens.
• Evaluated biosensing potential for high-affinity bio-recognition events.

Conclusions:

• Silver nanorod arrays are a robust platform for SERS-based detection.
• OAD is an effective method for fabricating these advanced biosensing substrates.
• These nanostructures hold significant potential for clinical diagnostics and biomedical applications.